Biomedical subjects

R E Kalbfleisch

Publications and source records attributed to R E Kalbfleisch.

3 recordsLinked to original sources

PubMed1993

Total abdominal hysterectomy at abdominal sacrovaginopexy: a comparative study.

OBJECTIVE: This study was designed to address whether women undergoing total abdominal hysterectomy at the time of abdominal sacrovaginopexy have a higher incidence of early postoperative febrile morbidity defined as an oral temperature > 35 degrees C (101 degrees F) on at least two occasions in the first 5 postoperative days when compared with women undergoing abdominal sacrovaginopexy alone. STUDY DESIGN: A prospective cohort study was performed in a tertiary care gynecologic urology clinic. Two hundred thirty-five patients were included in this study. Eighty-six (36.6%) underwent total abdominal hysterectomy in addition to abdominal sacrovaginopexy, whereas 149 (63.4%) had abdominal sacrovaginopexy alone, according to a standard protocol. Data were collected by chart review and analyzed with odds ratio and Student t statistics. RESULTS: The incidence of febrile morbidity was 4.7% in the group undergoing hysterectomy and 5.4% in the group having only abdominal sacrovaginopexy. The generated odds ratio (95% confidence interval) is 0.86 (0.21 to 3.28), which suggests no significant increase in febrile morbidity in the hysterectomy group. Similarly, no obvious difference was found in the duration of hospitalization or the change in hemoglobin between groups. There was, however, a significantly increased operating time in those patients undergoing hysterectomy. CONCLUSIONS: Total abdominal hysterectomy performed at the time of abdominal sacrovaginopexy does not result in a clinically significant increased risk of febrile morbidity.

Cohort Studies↗

PubMed1992

Prospective randomized study to compare a closed vault technique using absorbable staples at the time of abdominal hysterectomy versus open vault technique.

The current prospective randomized study in 102 women having a hysterectomy compared closed vault technique using absorbable staples with open vault technique. Fifty-six patients had the cuff stapled while 46 patients had the vault sutured open. The groups were equivalent with respect to indications for operation as well as other surgical procedures performed in conjunction with the hysterectomy, although more patients were randomized to open vault. No patient left the study. Operating time in the group with staples was 24 minutes (standard deviation of seven minutes) compared with 33 minutes (standard deviation of eight minutes) with the group with the open vault (p<0.0001). Hemostasis was also better in the group with staples (p<0.0001). The frequency of postoperative granulation tissue at the apex of the vaginal vault and the incidence of vaginal discharge during 12 weeks of follow-up evaluation were also less in the group with staples.

Adult↗

PubMed1987

The role of substance P in the human urinary bladder.

Detrusor muscle from human bladder contracted to field stimulation after atropine. It also responded to exogenous substance P by an atropine-insensitive mechanism. We tested whether substance P might mediate noncholinergic excitation. Tachyphylaxis to substance P did not effect noncholinergic responses to field stimulation. A substance P antagonist was ineffective in blocking responses to field stimulation or to exogenous substance P. Capsaicin had only nonspecific depressant effects on field stimulated contraction in high (10(-4) M) concentrations. These data do not support the hypothesis that substance P is the mediator of noncholinergic, field stimulated contractions of human detrusor muscle.

Atropine↗