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R E Knisley

Publications and source records attributed to R E Knisley.

12 recordsLinked to original sources
PubMed1992

Hemangioendothelioma of the spleen.

Hemangioendotheliomas of the spleen are rare and are considered to be of intermediate/borderline malignancy. We report such a case in a patient who presented with chronic anemia but who otherwise was asymptomatic. The tumor involved half the organ and was solitary and nonencapsulated. Microscopically, it was composed of vascular and stromal elements. Both types of elements showed moderate atypia and rare mitoses. The lining cells stained positively with antibodies to factor VIII-related antigen and Ulex europaeus lectin. The stromal component showed evidence of myofibroblastic differentiation. One year after splenectomy, all hematologic parameters slowly improved and returned to normal. The clinicopathologic differences between hemangioma, angiosarcoma, and hemangioendothelioma are discussed, and cases that have recently been reported in the literature are reviewed.

Hemangioendothelioma↗
PubMed1989

Primary non-Hodgkin's lymphoma of the esophagus.

Squamous cell carcinoma and adenocarcinoma constitute the majority of malignancies of the esophagus. Although lymphoma may involve any part of the gastrointestinal tract either primarily or secondarily, esophageal involvement is rare. We describe two cases of primary esophageal non-Hodgkin's lymphoma and review the literature, with particular attention to roentgenographic studies, esophagoscopic findings, and endoscopic biopsy results.

Aged↗
PubMed1980

Malignant lymphoma of Waldeyer's ring following gastrointestinal lymphoma.

Gastrointestinal involvement occurs in a greater proportion of patients with malignant lymphoma of Waldeyer's ring than would be accounted for by change alone. In the absence of direct lymphatic connection between these two sites, the association of these tumors has prompted several hypotheses: that the gastrointestinal lymphoma is a concomitant primary tumor; or that it is related to the swallowing and implantation of tumor cells; or that it represents the homing tendency of the gut-associated lymphoid tissue. Five cases are described in which malignant lymphoma of Waldeyer's ring developed ten months to five and half years after an initial diagnosis of gastrointestinal lymphoma was made. All five patients were female, and the original tumors were of the nodular lymphoma, histiocytic type in 4, and Lennert's lymphoma in 1. The tumors of Waldeyer's ring had similar cytologic features. In 1 patient with small intestinal lymphoma and recurrent tonsillar tumor five and half years later, immunoperoxidase staining of the original and recurrent tumors was positive with anti-IgA and anti-kappa antisera, thus establishing the identity of the two tumors. The reverse pattern of involvement, i.e., Waldeyer's ring tumor following gastrointestinal lymphoma, provides evidence against the concomitant primary or swallowing theories. The homing tendencies of gut-associated lymphoid tissue may offer some explanations for this interesting coincidence.

Adolescent↗
PubMedDate not supplied

Frequency of neoplasia in systemic lupus erythematosus and rheumatoid arthritis.

A patient population admitted to the hospital for either SLE or RA was surveyed for the subsequent development of neoplasms. The frequency of neoplasm in SLE patients appeared to be exaggerated, whereas the frequency of subsequent neoplasm in rheumatoid patients was unexpectedly low. A paucity of nephritis in the SLE group was noted. Further reports are encouraged so that the magnitude of the risk of malignancy developing with immunosuppressive therapy can be more precisely ascertained.

Adult↗