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Biomedical subjects

R E Mickel

Publications and source records attributed to R E Mickel.

14 recordsLinked to original sources
PubMed1989

Topical treatment of burns using aserbine.

A cream containing malic, benzoic and salicylic acid esters (Aserbine) was evaluated as a topical dressing for dermal burns. Children with thermal injuries covering less than 20 per cent of the body surface area (BSA) were treated with Aserbine (53 patients), Daromide (31 patients) or silver sulphadiazine (SSD) (16 patients). In these groups, hot liquids were the cause of injury in 92 per cent, 100 per cent and 80 per cent of patients respectively. There were no significant differences in the numbers of patients with clinical evidence of infection. Aserbine did not inhibit the growth of staphylococci or Ps. aeruginosa, partly inhibited beta-haemolytic streptococci and Proteus sp., and completely inhibited the growth of E. coli. The rate of wound healing did not differ significantly between the groups. No toxic effects of Aserbine were observed, apart from transient discomfort on application. Aserbine is a safe, inexpensive topical agent suitable for thermal burns which are not heavily contaminated.

Anti-Infective Agents, Local↗
PubMed1986

Abdominal muscular deficiency syndrome in a female child.

Abdominal muscular deficiency is a rare syndrome, which affects girls in less than 5% of cases. In addition, urinary tract involvement in females is unusual and these factors may suggest a sexual variation in the pathogenesis of the syndrome.

Abdominal Muscles↗
PubMed1985

Antenatal detection of a fetal ovarian cyst by real-time ultrasound. A case report.

A large fetal intra-abdominal cyst was detected on routine ultrasound scanning performed during the third trimester of pregnancy. This was not clinically obvious on routine examination after birth. Ultrasound contributed to the diagnosis and rational management of this case; we believe it should be performed routinely in the third trimester of pregnancy for the detection of unsuspected fetal abnormalities.

Adult↗
PubMed1983

A hospital outbreak of multiresistant Salmonella typhimurium belonging to phage type 193.

An outbreak of nosocomial infection was caused by strains of Salmonella typhimurium phage type 193 that were resistant to ampicillin, chloramphenicol, neomycin-kanamycin, streptomycin, spectinomycin, sulfonamides, tetracyclines, trimethoprim, and nalidixic acid. Resistances to drugs other than nalidixic acid were specified by plasmids, and, on the basis of phage typing and plasmid characterization studies, the multiresistant phage type 193 strains were determined to be clonal. In a two-year period, 488 patients infected with these bacteria were identified. An investigation in a pediatric surgical ward, where the outbreak was particularly severe, showed that patients exposed to antibiotics were more likely to be colonized with the epidemic strain and that young debilitated patients were more liable to show clinical signs of infection. Epidemiologic studies suggested that cross infection via the hands of the ward staff was the likely means of propagation of the epidemic.

Anti-Bacterial Agents↗
PubMed1980

Spontaneous perforation of the extra-hepatic bile ducts in neonates and infants.

Biliary ascites due to "spontaneous" perforation of the extra-hepatic bile ducts is uncommon, and should be suspected in an infant who, after a period of good health, develops jaundice and progressive abdominal distension. When the presentation is acute without jaundice the diagnosis is unlikely to be considered unless paracentesis is performed. The perforation is typically located in the common bile duct near its junction with the cystic duct and simple peritoneal drainage without suture is recommended unless the bile duct is obstructed, in which case T tube drainage or a bypass procedure is required. The prognosis is good. Four patients are presented who illustrate the spectrum of clinical presentation and the different methods of management. Two patients in whom the perforation was in the cystic duct were successfully treated by cholecystectomy. In most cases the aetiology is not apparent, but important factors may be weakening of the common bile duct wall due to ischaemia or pancreatic juice, reflux, associated with a rise in choledochal pressure. In older children the onset of biliary ascites may be preceded by an acute gastrointestinal illness, which may be a predisposing factor.

Ascites↗
PubMed1977

Cultural characteristics of mesoblastic nephromas.

Seven infants and children with renal tumors underwent nephrectomy and the tumors were cultured to investigate the behavior of their cells. In four children over 1 year of age with histologically typical nephroblastoma in the tumor cells were bizarre and disorderly. In one patient 3 months of age where the histology suggested malignancy the tumor culture showed an orderly growth pattern of spindle cells akin to normal kidney and the patient has had no recurrence for 18 months. In one infant seven months of age the histology was consistent with malignancy and this was confirmed on culture showing bizarre cells similar to those of nephroblastoma. The third infant under 1 year of age had a teratoma on histology and an unusual growth pattern on culture characterised by polyhedral cells with long processes and much overlapping. It is suggested that in infants with kidney tumors, tissue culture be used to help in assessing the malignant potential of the tumor and deciding on adjuvant therapy.

Child↗