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Biomedical subjects

R E Peck

Publications and source records attributed to R E Peck.

15 recordsLinked to original sources
PubMed2006

Intraocular pressure alterations following intravitreal triamcinolone acetonide.

AIMS: To determine the prevalence of intraocular pressure (IOP) alterations following intravitreal injection of triamcinolone acetonide (IVTA) and to assess possible risk factors of IOP elevation in eyes receiving single and/or repeat injections. METHODS: Retrospective, consecutive case series. 570 consecutive eyes of 536 patients who received a single IVTA injection (4 mg/0.1 ml) and a second set of 43 eyes of 40 patients who received a second injection. Retrospective review of all IVTA cases performed by three vitreoretinal surgeons over a 42 month period beginning in 2000. The main outcome measure was change in IOP defined as absolute value of IOP elevation (5 mm Hg or higher, 10 mm Hg or higher), and percentage of baseline (30% or higher increase from baseline IOP). RESULTS: Of the 528 eyes receiving single injections, 281 (53.2%) had an IOP elevation; 267 eyes (50.6%) experienced an elevation of IOP of at least 30%, and 245 (45.8%) and 75 (14.2%) eyes had an increase of 5 mm Hg or 10 mm Hg or more, respectively. Baseline IOP greater than 16 mm Hg is a risk factor for post-injection IOP elevation. Of the 43 eyes which received a second injection, 28 (65.1%) experienced an increase in IOP of at least 30% of baseline. Filtering surgery was required in five (0.094%) of the single and one (2.3%) of repeat injection eyes. CONCLUSIONS: Elevated IOP after IVTA is common and patients should be monitored beyond 6 months post-injection. Patients with a baseline IOP more than 16 mm Hg or receiving a second injection should be carefully monitored for an elevated IOP.

Adolescent↗
PubMed1984

Leukotriene C synthetase, a special glutathione S-transferase: properties of the enzyme and inhibitor studies with special reference to the mode of action of U-60,257, a selective inhibitor of leukotriene synthesis.

The cytosolic glutathione S-transferases of rat liver have been fractionated by chromatofocusing into 10 distinct fractions based on their reactivity with 2,4-dinitrochlorobenzene. All these fractions were capable of generating leukotriene C4 (LTC4) from leukotriene A4 (LTA4) to some extent. An inhibitor of leukotriene synthesis, U-60,257, inhibited the activity of these enzymes. The cytosolic glutathione S-transferases of rat basophil leukemia (RBL) cells have been similarly fractionated. U-60,257 inhibited the activity of some of these fractions but not that of others. None of the fractions of the enzyme from RBL cells formed LTC4 from LTA4. The microsomal glutathione S-transferase from rat liver also produced LTC4 from LTA4. It differs from the microsomal LTC synthetase of RBL cells in at least two respects: (1) The enzyme from RBL cells did not react with chromophoric substrates like dinitrochlorobenzene while the enzyme from liver did react. (2) Triton X-100 potentiated the activity of the enzyme from basophil leukemia cells and solubilized it, while it inhibited the activity of the leukotriene-synthesizing enzyme in the rat liver preparation. These results, along with a distinctly different inhibitor profile, indicate that LTC synthetase is a new and distinct glutathione S-transferase.

Animals↗
PubMed1981

Nutritional status of Southeast Asian refugee children.

Since 1975 nearly 300,000 Indochinese refugees have been relocated in the United States. The Nutrition Division, Centers for Disease Control. Atlanta, surveyed the medical records of four west coast clinics to obtain nutrition-related data on 821 Southeast Asian refugee children under six years of age, arriving between July 1979 and June 1989. Hemoglobin, hematocrit, and anthropometric data were compared to those of a comparison group of Southeast Asian children screened prior to 1979 and to a National Health Examination Survey reference population. The newly-arrived refugee group was found to be highly anemic and stunted relative to the comparison group. Although stunted, the study group did not appear greatly wasted.

Anemia↗
PubMed1975

Similarities between parents and offspring on a personality inventory.

The authors administered a personality inventory that has been used as a psychiatric screening test to 28 children and their natural parents. By intercorrelations between the tests of parents and offspring they attempted to find out whether the offspring resembled the parent of same sex, the parent of the opposite sex, or a composite of both parents. They found that the offspring resembled their peer group more often than either parent or a composite of both parents.

Adolescent↗
PubMedDate not supplied

Birth weight and subsequent growth among Navajo children.

An examination of length, weight, and birth weight data routinely collected from the clinics supported by the Navajo Nation Special Supplemental Program for Women, Infants, and Children (WIC) showed an association between birth weight and subsequent growth status. Navajo children less than 2 years of age entering the WIC Program were divided into low, normal, and high birth weight groups, and their growth patterns were plotted when they returned periodically for reassessment. Overall, the children tended to have low length-for-age and high weight-for-length measures, relative to the reference population, that suggest suboptimal nutritional status. Children with birth weights less than 2,500 grams (g) were consistently shorter, lighter, and thinner than children with birth weights greater than 2,500 g. Although the overall growth status of the children improved between 1975 and 1980, the growth among the children with low birth weights never fully caught up with that of the other Navajo children. Moreover, during that period, the normal birth weight group had a modest improvement in length-for-age relative to the reference population, but the low birth weight group did not. These findings suggest that prenatal interventions to improve the birth weight status of Navajo infants may result in improving the growth status of Navajo children.

Birth Weight↗