PubMed Health⌕ Search

Biomedical subjects

R E Reese

Publications and source records attributed to R E Reese.

9 recordsLinked to original sources
PubMed1988

RO 15-4513 does not protect rats against the lethal effects of ethanol.

In two separate research centres the ability of RO 15-4513 to protect rats against the lethal effects of ethanol (7.5 and 15 g/kg) was investigated. In neither study did RO 15-4513 offer protection against ethanol-induced lethality or the loss of righting reflex caused by these doses of ethanol. These data fail to replicate the results of an earlier report and suggest that RO 15-4513 is unlikely to be clinically useful treating acute severe ethanol toxicity.

Animals↗
PubMed1987

Trimethoprim-sulfamethoxazole and other sulfonamides.

Trimethoprim-sulfamethoxazole continues to be a useful antibiotic for common outpatient problems such as urinary tract infections, prostatitis, acute exacerbations of chronic bronchitis, and acute otitis media as well as for serious infections of the hospitalized patient including Pneumocystis carinii pneumonia, acute pyelonephritis, and some forms of gram negative meningitis. The other sulfonamides have a limited role.

Anti-Infective Agents↗
PubMed1986

Hypoprothrombinemia associated with cefamandole use in a rural teaching hospital.

The incidence of hypoprothrombinemia (prothrombin time greater than or equal to 2 s above the highest control) associated with concurrent cefamandole nafate usage in our institution was determined. Of 77 patients receiving cefamandole for no less than 48 hours, serial prothrombin time was monitored in 31 (40.2%). Four (12.9%) of 31 in whom a baseline normal prothrombin time was obtained developed hypoprothrombinemia during cefamandole therapy. An additional three patients for whom baseline prothrombin time was not determined were noted to have hypoprothrombinemia during therapy with cefamandole. Two patients had clinically significant bleeding episodes. The prothrombin time normalized in six of seven patients following administration of fresh frozen plasma, phytonadione therapy, discontinuation of cefamandole, or a combination of the three. This study illustrated that the incidence of hypoprothrombinemia associated with concurrent cefamandole use is relatively high. Serial prothrombin time monitoring is indicated when patients receive cefamandole.

Adult↗
PubMed1985

Massive diarrhea in Legionella micdadei pneumonitis.

Mild diarrhea of poorly documented volume is common early in the course of Legionella infection. We report massive diarrhea of 1.8 to 3 liters per day in a patient with pneumonia in whom Legionella micdadei was isolated from pleural fluid and infection was confirmed serologically. The large volume of diarrhea, not previously associated with Legionella infection, remained unexplained despite clinical evaluation and postmortem study of the gastrointestinal tract. This case expands the clinical spectrum of Legionnaires' disease to include massive diarrhea, which in our patient constituted the chief complaint.

Diarrhea↗
PubMed1976

In vitro susceptibility of common clinical anaerobic and aerobic isolates against josamycin.

The in vitro susceptibility of 145 anaerobic clinical isolates and 96 gram-positive aerobic clinical isolates to josamycin, a new macrolide antibiotic, was studied using the agar dilution technique. Ninety-five of the aerobes were susceptible to 1.56 mug or less of josamycin per ml. The median minimal inhibitory concentration of these organisms was </=0.39 mug/ml. The in vitro activity of josamycin against the anaerobes was compared with that of erythromycin, clindamycin, penicillin, and chloramphenicol. At concentrations </=3.12 mug/ml, 100% of strains of Bacteroides species and Bacteroides fragilis were susceptible to josamycin. At low concentrations (</=0.39 mug/ml), clindamycin was more active than josamycin against the anaerobes. However, at concentrations </=3.12 mug/ml, the activities of josamycin and clindamycin were similar except against the Fusobacterium species, which was quite resistant to josamycin.

Aerobiosis↗