Biomedical subjects

R E Simon

Publications and source records attributed to R E Simon.

3 recordsLinked to original sources

PubMed2001

Fluorescence quenching high-performance thin-layer chromatographic analysis utilizing a scientifically operated charge-coupled device detector.

A scientifically operated charge-coupled device detector combined with fluorescence quenching high-performance thin-layer chromatographic plates was employed for the detection of organic compounds, The plates were excited with 254 nm light from a mercury lamp, and quantitative information was obtained from organic compounds that absorbed the optimum conditions for detection. The linear dynamic range, sensitivity, and reproducibility of the system were evaluated by quantitative analysis of famotidine, acetaminophen, caffeine, and acetylsalicylic acid. The detection limits of the system were found to be in the nanogram range.

Acetaminophen↗

PubMed1999

Utilization of a scientifically operated charge-coupled device detector for high-performance thin-layer chromatographic analysis of tetracyclines.

A high-performance thin-layer chromatography (HPTLC) method using a scientifically operated charge-coupled device detector is described for the assay of tetracycline pharmaceutical products. Quantitative information can be obtained for all samples on a TLC plate within a few seconds. The separation efficiency and detection limits were determined on both normal phase and reverse phase TLC plates. Fluorescence detection mode offers higher sensitivity than fluorescence quenching mode. The dynamic range, sensitivity, accuracy and precision of the system were evaluated. Detection limits of the impurities are in the range of 0.1 to 0.5 ng or 0.3 to 1% of tetracycline, depending on the compound, with a recovery percentage over 85%. The existing impurities in tetracycline capsules were determined using both HPLC and HPTLC techniques. All of the impurities were below the regulation level.

Anti-Bacterial Agents↗

PubMedDate not supplied

Ibuprofen suspension: pediatric antipyretic.

Pediatric ibuprofen suspension has been available by prescription for relief of fever in children age 6 months and older since 1989. A review of several studies shows this drug to be a safe and effective antipyretic in children as young as 3 months of age. Doses of 10 mg/kg have been demonstrated to provide more rapid antipyresis of longer duration than the same dose of acetaminophen, especially in the presence of high fever (> or = 101.9 degrees F). These factors prompted manufacturers to seek approval for sale of this drug without prescription.

Analgesics, Non-Narcotic↗