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R E Snyder

Publications and source records attributed to R E Snyder.

65 records · Page 4Linked to original sources
PubMedDate not supplied

Relationships between the rapid axonal transport of newly synthesized proteins and membranous organelles.

Rapid axonal transport is generally viewed as being exactly analogous to the secretory process in nonneuronal cells. The cell biology of rapid axonal transport is reviewed, the central concern being to explore those aspects that do not fit into the general secretory model and which may thus represent specific neuronal adaptations. Particular attention is paid to the relationship between the transport of newly synthesized proteins and of the membranous organelles that act as carriers. Sites in the transport sequence at which the behavior of axonal transport may differ from the secretory model are at the initiation of axonal transport at the trans-side of the Golgi apparatus, within the axon where molecules are deposited from the moving phase to a stationary phase, and at nerve terminals or axonal lesions where transport reversal takes place.

Animals↗
PubMedDate not supplied

Protein loss from axonal transport occurs without diminution of vesicle traffic.

Protein loss from the rapid anterograde axonal transport system of amphibian sensory nerve fibers was compared with the numbers and sizes of anterogradely transported vesicles in the axons. Protein was found to be lost at a rate of approximately 2% per millimeter of nerve traversed. However, no changes were observed in either the numbers or sizes of vesicles in the nerve at two locations separated by 60-75 mm. The results show that protein loss is not explained as a loss of vesicles from the transport system nor by a reduction in vesicle size.

Animals↗
PubMedDate not supplied

Socioeconomic differences in Medicare supplemental coverage.

In this study we compare the beneficiaries with various types of Medicare supplemental insurance coverage to examine the impact of socioeconomic characteristics on such coverage. We found that those who are more disadvantaged are less likely to have any coverage, and those who have it are less likely to have it subsidized by a former employer. These findings have direct implications for the fairness of proposed programs to provide prescription drug coverage to Medicare beneficiaries, and for the advisability of various proposals for reforming Medicare, including "premium-support" programs.

Drug Prescriptions↗
PubMedDate not supplied

Foetal alcohol syndrome in Saskatchewan: unchanged incidence in a 20-year period.

Despite major initiatives in public and professional education about foetal alcohol syndrome (FAS) in Saskatchewan in the last 20 years, its incidence rate has not fallen. The rate was 0.515 per 1,000 live births in 1973-1977 and 0.589 in 1988-1992. Two hundred and seven (207) cases were ascertained, the majority being patients of the Alvin Buckwold Child Development Program in Saskatoon. These individuals were severely handicapped: 72% had at least one malformation, the mean intelligence quotient was 67.8 (range 35-106) and 45.9% had a behaviour problem. Only 25.6% still lived with their biological parents when last seen, and only 27 of 108 cases were in a regular class at school without additional support being necessary. New approaches are needed to reduce the incidence of FAS. Emphasis should be placed on individual case-finding, counselling for high-risk women, and community development programs. We are currently attempting this through a provincial coordinating committee.

Adolescent↗