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Biomedical subjects

R E Sturm

Publications and source records attributed to R E Sturm.

At least 19 recordsLinked to original sources

Human centrifuge non-invasive measurements of arterial pressure at eye level during Gz acceleration.

An apparatus for successful repetitive, indirect photokymographic recordings of systolic blood pressure (Ps) on a human centrifuge during World War II is described. Proportionately to 1 Gz hydrostatic heart-to-head Ps differences, eye level Ps decreased approximately 30 mm Hg per delta G, during 15 s Gz exposures of three relaxed volunteers, a finding confirmed subsequently by continuous intra-arterial pressures in 18 subjects. At 2 G.s-1 onset rates, maximal decreases occurred within 7 s after 1.5 Gz followed by compensatory recoveries while acceleration was maintained. Contours of simultaneously recorded decreases in ear opacity (blood content) were closely similar. Anti-G suit protection against subjective visual symptoms was similar to objective decreases in ear blood content but significantly less than against decreases in Ps at eye level. This may be due to relatively higher intraocular pressures secondary to increased intra-abdominal, cerebrospinal fluid and venous pressure produced by inflation, particularly of the abdominal bladder of the suit.

Acceleration

Quantitative imaging of the structure and function of the heart, lungs, and circulation.

A 28-x-ray-source, cylindrical-scanning, transaxial tomographic x-ray-imaging system is in the process of being fabricated. This system will scan synchronously up to 250 parallel transverse cross sections of the human body over an axial range of 25 cm within 0.01 second at a maximum rate of 60 scans per second. The system will provide numerous variations of scanning configurations to permit quantitative assessment of the relative importance of transverse section thickness, image contrast, spatial and temporal resolution, and related computerized algorithms and display techniques. Synchronous imaging at high temporal resolution of a three-dimensional volume--for example, the heart--eliminates the need for successive periods of breath-holding and gated imaging techniques and is essential for quantitation of cardiovascular and pulmonary function and structure in intact animals or humans. Initial clinical applications are expected to be in the early detection of lung cancer and the diagnosis of the nature and degree of congenital and acquired cardiovascular disabilities.

Animals

A charge coupled transversal filter for biomedical signal conditioning.

The analysis and processing of biological signals is often hampered by the contamination of these low frequency, often low amplitude waveforms by motion artifact in fluid-filled catheter systems and skin electrodes, power line hum, and so on. Although noise suppression techniques have relied upon low pass filtration of the analog signals with active or passive RLC filters, even the most recent active RLC filter implementations display operational characteristics not entirely satisfactory for low frequency applications.

Analog-Digital Conversion