Ankylosing spondylitis presenting as PUO.
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Biomedical subjects
Publications and source records attributed to R Ebringer.
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A search for the presence of Klebsiella-Enterobacter spp. and Yersinia enterocolitica in urine and faeces of 63 patients with ankylosing spondylitis was conducted because these microorganisms have been demonstrated to cross-react immunologically with HL-A B27 positive lymphocytes. The patients were graded into three groups on the basis of disease activity. Klebsiella spp. were found in the faeces of 13 (93%) of the 14 patients with 'active' disease, 10 (48%) of the 21 patients with 'probably active' disease and in one (4%) of the 28 patients with 'inactive' disease. Positive cultures were also obtained in 47 (38%) of 124 controls. It is suggested that the presence of Klebsiella spp. in faecal cultures may be associated with 'active' disease in patients with ankylosing spondylitis.
Various haemodynamic measurements were correlated with the A2-OS interval in 35 patients with pure or predominant mitral stenosis. There was good correlation of left atrial V wave pressure, left ventricular systolic pressure, and mitral mean diastolic gradient with A2-OS. There was no significant correlation of mitral valve area with A2-OS. When the left ventricular pressure was arbitrarily assigned to one particular pressure (100 mm. Hg) correlations with all other variables improved. There was still no correlation of A2-OS interval with mitral valve area. These and other haemodynamic factors influencing the A2-OS interval are briefly discussed.