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Biomedical subjects

R Ertan

Publications and source records attributed to R Ertan.

22 records · Page 2Linked to original sources
PubMed1992

Synthesis and antipseudomonal activities of some ofloxacin esters as prodrugs.

Three new ofloxacin esters have been synthesized as prodrug by the reaction of ofloxacin (CAS 82419-36-1) with chloromethylacetate, 1-chloroethylacetate and 1-chloroethylethylcarbonate in acetonitrile. The structures of the compounds have been elucidated by UV, IR, 1H-NMR, Mass spectra and elementary analysis. In vitro activities of these compounds against clinical isolates of various Pseudomonas aeruginosa species have been determined by microtiter tube dilution method, and octanol/water partition coefficients and pH dependent hydrolysis rates have been investigated in comparison with ofloxacin.

Chemical Phenomena↗
PubMed1991

Synthesis and antifungal activity of some new benzimidazole derivatives.

Synthesis and antifungal evaluation of 5-ethoxycarbonyl-2-(substituted-benzyl or phenoxymethyl)benzimidazoles are reported. Structures of the compounds were elucidated with IR-, 1H-NMR-, 13C-NMR-, mass-spectra and elemental analysis. Preliminary results show that none of the synthesized benzimidazole derivatives has antifungal activity at the concentration of 100 micrograms/ml against Candida parapsilosis, Candida stellatoidea, and Candida pseudotropicalis.

Antifungal Agents↗
PubMed1989

Synthesis of new annellated flavonoid derivatives possessing spasmolytic activity--VII.

7,8-Dihydroxyflavone reacts with ethyl 2,3-dibromopropanoate to form the new, annellated, 1,4-benzodioxanes 1 containing a flavone structural unit. The regioisomers 1a and 1b thus obtained were separated and 1a was converted to the amides 2a-2f. The constitutions of 1 and 2 were elucidated by 500 MHz 1H-NMR spectroscopy. In the spasmolysis test, 2e showed significant antagonistic effect towards the agonists acetylcholine, barium chloride, and histamine.

Chemical Phenomena↗