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Biomedical subjects

R Eyjolfsson

Publications and source records attributed to R Eyjolfsson.

10 recordsLinked to original sources

Nitrofurantoin: particle size and dissolution.

Tablets manufactured from micronized anhydrous nitrofurantoin exhibited unsatisfactory dissolution properties, whereas excellent results were obtained with unmilled drug material having fine particle size.

Nitrofurantoin↗

Hydroxypropyl methylcellulose mixtures: effects and kinetics of release of an insoluble drug.

Matrix tablets manufactured from a practically insoluble drug using Methocel K4M, Methocel K100LV, and mixtures thereof exhibited non-Fickian dissolution properties governed by both diffusion and erosion (value of diffusional exponent in Peppas's transport equation 0.7). The effects of these two hydroxypropyl methylcellulose (HPMC) varieties were nonlinear and antagonistic.

Diffusion↗

Lisinopril-lactose incompatibility.

A chemical interaction between lisinopril and lactose was demonstrated and quantified in dilute mixtures in the solid state.

Drug Incompatibility↗