PubMed Health⌕ Search

Biomedical subjects

R F Aĭziatulov

Publications and source records attributed to R F Aĭziatulov.

13 recordsLinked to original sources
PubMed2003

[Derivatives of cholecalciferol in the treatment of psoriasis].

The review of the literature is devoted to derivatives of calciferol (vitamin D3), representatives of a new group of antiproliferative drugs employed in psoriasis, ichthyosis, rheumatism and some neoplastic processes. Results are submitted of histo- and biochemical, physiological, and clinical trials of the synthetic derivative of vitamin D calcipotriol, a possibility of its combination with physiotheraputic modes of treatment is reported together with recently identified side effects. Novel analogues of the drug are listed, with their merits and demerits pointed out. The authors conclude that further studies are warranted into abnormalities of metabolism of calcium in psoriasis to develop efficacious modes of correction of dermatosis involving the use of representatives of the given group of medicinal agents.

Calcium↗
PubMed1990

[Morphofunctional changes in the skin in foot mycosis].

Sixteen specimens of cadaveric intertoe folds of patients who had suffered from intertrichinous mycoses of the soles (miners who died in accidents or because of traumas) were examined by histologic and histochemical methods. For control intertoe fold specimens from 10 suddenly dead workers without mycoses were examined. Examinations of skin specimens from mycosis foci have revealed fungus mycelium in the epidermis and superficial layers of the derma, focal perivascular infiltrates consisting mainly of T-lymphocytes (a positive reaction to alpha-naphthylacetate esterase), macrophages, sensitized lymphocytes (high acid phosphatase activity); this necessitates administration, along with mycocidal agents, of angioprotectors, proteolysis inhibitors, immunostimulants. Histoenzymologic studies have revealed impairments of the principal components of metabolism and activation of glycolysis processes. Less manifest changes were revealed in apparently intact skin, this being an evidence of a systemic involvement of the skin in a prolonged mycotic process.

Biopsy↗
PubMed1990

[The significance of occupational factors in the pathogenesis of foot mycoses in miners in deep coal mines].

Skin and peripheral vessel functions, allergic status of the body, lysosomal enzymes activities, lipid peroxidation and antioxidant system status were examined in 280 coal miners suffering from mycoses of the soles, as were their working conditions, in order to clear out some aspects in the pathogenesis of this condition. The data evidence grave disorders of the function of the skin and peripheral vessels of the limbs, of the allergic status of the body, and of lipid peroxidation and antioxidant system, this pointing to a possible contribution of occupational factors to some aspects in the pathogenesis of mycoses of the soles.

Antioxidants↗
PubMed1990

[Familial mycotic infection in coal miners].

Communal and hygienic conditions have been examined in families of 50 miners with a history of mycoses of the feet. Mycotic infection has been detected in 44 of 121 members of their families. Infection in the families is explained by neglect of preventive measures, inadequate hygienic conditions, and nonobservance of individual prophylaxis rules.

Adolescent↗
PubMed1990

[Undiagnosed early secondary syphilis with horny palmar and plantar papules].

A 20-year-old female patient is described who contracted syphilis in a rape attempt. She consulted a dermatovenereologist twice but the disease was not diagnosed, for despite the fact that the patient had hard chancre fragments on the posterior adhesion of the vagina, polyscleradenitis, abundant roseolar eruption on the trunk skin, horny palmar and plantar papular efflorescence, erythematous syphilitic tonsillitis, she was not examined nor serological tests were carried out. The condition was diagnosed as callosity and acute respiratory viral disease, antihistaminic and antibiotic drugs were prescribed. The condition was diagnosed only in a month after the first visit to a doctor.

Adult↗
PubMed1989

[The histamine-serotonin-monoamine oxidase system in patients with foot mycosis during treatment].

Examinations of 18 patients with mycoses of the foot complicated by allergic processes, have revealed elevated blood serum concentrations of histamine, serotonin, cathepsin D, and acid phosphatase, and a lowered activity of monoamine oxidase, as compared to 22 patients with mycoses not complicated with allergic manifestations. This fact reflects one of the aspects of a pathogenetic difference between these patients and necessitates combined therapy to correct the detected abnormalities.

Acid Phosphatase↗