Biomedical subjects

R F Butterwick

Publications and source records attributed to R F Butterwick.

6 recordsLinked to original sources

PubMed1997

Effect of amount and type of dietary fiber on food intake in energy-restricted dogs.

OBJECTIVE: To evaluate the effect of adding different amounts of insoluble (IF) or soluble (SF) dietary fiber to a commercial diet formulated for weight reduction on satiety and perception of hunger in dogs. ANIMALS: 6 adult dogs. PROCEDURE: Test diets included 2 low-fiber control diets (CL1 and CL2), 2 diets with increased amount of IF (IF1 and IF2), and 2 diets with increased amount of SF (SF1 and SF2). Each test diet was fed for 12 days to 6 dogs in a Latin square design, and in amounts that correspond to the food allowance recommended for weight reduction. Behavioral characteristics of dogs were recorded for 30-minute periods after introduction of test diets. On 2 occasions during each test period, exactly 3 hours after feeding of the test diet, dogs were given a challenge meal consisting of a standard commercial canned dog food ad libitum. At the end of each 12-day feeding period, all dogs entered a 6-day washout period in which they were offered a standard commercial canned dog food ad libitum. RESULTS: Diet had no significant effect on intake of the challenge meal, intake of food during the subsequent washout period, or perception of hunger, as represented by behavioral characteristics during the 30-minute period after presentation of test diets. In addition, diet had no significant effect on percentage of weight loss. CONCLUSIONS: Inclusion of high amounts of IF or SF in a commercial low-energy diet has no apparent beneficial effects on satiety when fed to dogs on an energy intake regimen corresponding to allowances for weight reduction.

Animal Feed↗

PubMed1996

Changes in the body composition of cats during weight reduction by controlled dietary energy restriction.

Thirteen overweight domestic short-haired cats were fed a commercial low calorie diet for 18 weeks at an energy intake to lose weight; they lost an average of 18.1 per cent of their starting weight. An evaluation of their body composition by dual energy x-ray absorptiometry before and after the study suggested that most of the weight lost was composed of fat. The cats' lean bodyweight did not change significantly, but increased as a proportion of total bodyweight.

Absorptiometry, Photon↗

PubMed1995

Development of methods for analyzing plasma lipoprotein concentrations and associated enzyme activities and their use to measure the effects of pregnancy and lactation in cats.

Methods available for measurement of plasma lipoprotein-cholesterol concentrations and activities of lipoprotein lipase, hepatic lipase, lecithin:cholesterol acyl transferase (LCAT), and cholesteryl ester transfer protein were adapted for use in cats. A combined ultracentrifugation/precipitation procedure was used to isolate very low-density lipoproteins (VLDL), then to separate low-density lipoproteins (LDL) from high-density lipoproteins (HDL). The reagent used, 92 mM heparin-manganese chloride, provided complete precipitation of LDL with only trace and insignificant contamination by HDL. Efforts to selectively measure lipoprotein lipase activity in plasma, collected after IV injection of heparin, by inhibiting hepatic lipase with sodium dodecyl sulfate were unsuccessful, and the activity of this enzyme was calculated as the difference between total and hepatic lipase activities. The latter was measured in the presence of high salt concentration to inhibit lipoprotein lipase. Cholesterol esterifying activity was identified in feline plasma and was typical of LCAT, in that it was dependent on apolipoprotein A-I as a cofactor. The intra-assay and interassay coefficients of variation for measurement of lipoprotein lipase, hepatic lipase, and LCAT activities were 18.4, 4.6, and 7.2%, and 20.4, 10.7, and 5.3%, respectively. Appreciable cholesteryl ester transfer protein activity was not detected in either undiluted or diluted plasma. These methods were subsequently used to investigate the effects of pregnancy and lactation on lipoprotein metabolism in a group of 10 queens. Plasma concentrations of cholesterol and triglycerides were unaltered during pregnancy, but the concentrations of VLDL-cholesterol increased and those of HDL-cholesterol decreased.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗

PubMed1994

A study of obese cats on a calorie-controlled weight reduction programme.

Twenty-two domestic cats were fed a commercial low calorie diet for the management of obesity for up to 18 weeks and showed an average weight loss of 13.5 per cent of their body-weight. There was no indication that a steady weight loss over the study period had any adverse effect on the hepatic function or general health of the cats. There was an increase in the cats' total serum cholesterol concentration in association with the loss of weight.

Animals↗

PubMed1994

Effect of level and source of dietary fiber on food intake in the dog.

The effects of dietary fiber on challenge meal intake and on the perception of hunger in dogs were evaluated. A program of testing variants of a standard low energy diet, to which one of five fiber containing raw materials was added, was undertaken. Diets were fed to a group of six dogs for 12-d periods in a latin square design and in amounts that corresponded to the food allowance for weight reduction. Behavioral characteristics of dogs were recorded on videotape for 30-min periods after introduction of test diets. On two occasions during each 12-d feeding period dogs were presented with a challenge meal. At the end of each 12-d feeding period all dogs entered a 6-d washout period. There was no significant effect of diet on the intake of the challenge meal or on intake of food during the subsequent washout period. In addition, diet had no apparent effect on the perception of hunger, as represented by behavioral characteristics during the 30-min period after presentation of test diets. It was concluded that inclusion of moderate levels of raw materials, composed primarily of insoluble fiber, in a commercial low energy diet had no apparent beneficial effects on satiety, when fed to dogs on an energy intake corresponding to allowances for weight reduction.

Animal Feed↗

PubMed1994

Clinical studies in the management of obesity in dogs and cats.

Obesity in companion animals is a common clinical condition, and represents an important challenge to the veterinarian. This paper reports a study in which controlled calorie reduction was used to achieve weight loss in a group of dogs. The food allowance for the study provided approximately 209 kJ metabolisable energy (ME)/kg (target weight)0.75/day, with target weight 15% less than the dog's starting weight. The rate of weight loss achieved averaged approximately 1% per week over a 12 week period. Data reviewed from a second study in cats suggested that an energy intake of approximately 121 kJ ME/kg target weight/day, again with the target 15% less than the current weight, was an appropriate level for obtaining gradual weight loss in this species. These findings are discussed in relation to an alternative method of weight reduction, starvation. The potential value of exercise as an adjunct to controlled calorie reduction for achieving weight loss in companion animals is also considered.

Animal Feed↗