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Biomedical subjects

R F Eliseeva

Publications and source records attributed to R F Eliseeva.

15 recordsLinked to original sources
PubMed1982

[Changes in the blood uric acid levels in patients with retinitis pigmentosa and in rats with hereditary retinal degeneration].

The content of uric acid was measured in the blood of patients suffering from retinitis pigmentosa, as well as in the blood, retina, brain, liver and urine of rats with inherited retinal degeneration in the course of postnatal development. It was found that in the patients with retinitis pigmentosa, the concentration of uric acid in the blood serum was 50% higher as compared to normals. On the 8th day of life the content of uric acid in the blood of the sick rats was equal to 150% as compared to the normal animals. This difference persisted during the subsequent postnatal life. In the rats with inherited retinal degeneration, the content of this purine in the retina, brain and liver was approximately the same as that seen in the normal animals in all the studied periods of life. Meanwhile statistically significant changes in the uric acid content in the sick animals' urine appeared at an age of 1.5-2 months. It is believed that the identical line of changes in the uric acid content in the blood of the sick persons and rats points to similarity of the experimental disease of the animals to the disease in humans.

Animals↗
PubMedDate not supplied

[Time course of bioelectrical activity of retina in patients with pigmented abiotrophy treated by deoxinate].

Bioelectrical retinal activity was assessed before and after a course of deoxinate therapy and in a blind placebo test in order to assess the efficacy of this new drug in the treatment of patients with pigmented retinal abiotrophy. Time course of electroretinograms during deoxinate therapy indicated a significant positive effect of the drug on retinal function as regards a variety of electrophysiological parameters in 80-94% patients. Improvement of electroretinography data was paralleled by improvement of visual acuity, extension of visual fields, and decrease of scotomas. Good effect was attained in patients with early and far advanced stages of pigmented retinal abiotrophy. Analysis of bioelectrical activity of the retina after a course of therapy with deoxinate and enkad showed a higher efficacy of the former drug in patients with pigmented retinal abiotrophy.

Adjuvants, Immunologic↗
PubMedDate not supplied

[Pathological changes in the eyeball in tapetoretinal abiotrophy].

The authors sum up the results of comprehensive examination of all the principal structures of the eyeball in patients with tapetoretinal abiotrophy. Present-day methods of investigation were employed, that helped reveal a generalized pattern of the pathologic process in this condition. The detected shifts should be borne in mind when choosing a method for cataract extraction in such patients.

Adult↗
PubMedDate not supplied

[Trans-scleral cryopexy in hemophthalmos of diabetic etiology].

Trans-scleral cryopexy (TSC) was carried out in 81 eyes with recurrent hemophthalmos of diabetic genesis. 73 patients were followed up after surgery for a period of 3 months to 5 years. Hemophthalmos resolved in 80 percent of eyes (completely in 60, partially in 20 percent). The condition recurred in 10 percent of eyes, detachment of the retina developed in 13, neovascular glaucoma in 4 percent, and cataract progressed in 10 percent of eyes. Vision acuity improved in 36 percent of eyes; the best results were observed in type II diabetes mellitus. TSC proved to be an effective method for the management of hemophthalmos of diabetic nature.

Adult↗