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Biomedical subjects

R F Frongillo

Publications and source records attributed to R F Frongillo.

At least 37 records · Page 2Linked to original sources
PubMed1982

[Epidemiological results in recovered cases of viral hepatitis at the Infectious Disease Clinic of the University of Perugia from 1971 to 1978].

A retrospective epidemiological survey on patients admitted for hepatitis to the Infectious Disease Institute of Perugia University was undertaken. 255 out of 610 patients, examined during the 1971-1978 period, had type B hepatitis. The incidence of post transfusional hepatitis was 15.7%, while the disease showed significant increase in drug addict patients and in hospital staff. HBsAg was positive in 40 of 94 patients (43.7%) with post-transfusional hepatitis.

Adolescent↗
PubMed1981

Suction skin blister, skin window, and skin chamber techniques to determine extravascular passage of cefotaxime in humans.

We report the results obtained in comparative study on the extravascular passage of cefotaxime, employing three different methods: suction skin blister, skin window, and skin chamber. Applying the skin blister method in two different ways, we also studied the influence that suction pressure and time lapse between blister formation and antibiotic injection had on the results obtained in order to standardize the method and establish repeatability of the results. Using the skin chamber method, we studied the influence that the different protein contents in the fluid used to fill the skin chamber had on extravascular concentrations.

Adolescent↗
PubMed1980

A comparison of the activity in vitro of different cephalosporins: cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime and cefotaxime.

6-cephalosporins (cephalothin, cephradine, cephacetrile, cefaclor, cefuroxime, cefotaxime) has been tested in vitro against 212 gram negative bacteria and 60 Staphylococci. Cefuroxime and especially Cefotaxime showed the highest activity against the gram negative bacteria, with a very low MIC. Cefotaxime also acted fairly well against several strains of Pseudomonas. Of the six cephalosporins tested, cephalothin gave the best results against the Staphylococci.

Cefaclor↗
PubMed1978

[Hepatitis B and non-B in our case reports of post-transfusional hepatitis].

The Authors examined 52 patients with post-transfusional hepatitis admitted in the Insitute of Infectious Diseases in Perugia, from 1971 to 1977. 30 (57.7%) patients had "B" hepatitis, 22 (42.3%) "non B" hepatitis. The incidence of anti-HBs antibodies in the two groups of patients suggests that they are partially protective against "B" hepatitis. "B" and "non B" hepatitis resulted clinically different only in the incubation period, 95.6 days (mean) for "B" hepatitis and 62.1 days (mean) for the "non B" hepatitis.

Hepatitis B↗
PubMedDate not supplied

Empiric antimicrobial therapy in febrile granulocytopenic patients. Randomized prospective comparison of amikacin plus piperacillin with or without parenteral trimethoprim/sulphamethoxazole.

In a prospective randomized trial parenteral trimethoprim/sulphamethoxazole was added to amikacin plus piperacillin in order to compare triple-drug antibiotic combination with a standard regimen as empiric therapy of fever in patients with granulocytopenia. One hundred and sixty-one episodes were evaluated; 74 episodes with amikacin plus piperacillin and 87 episodes with amikacin plus piperacillin plus trimethoprim/sulphamethoxazole. The overall response to therapy (63% vs. 84%) as well as the response of microbiologically documented infections (60% vs. 82%) was significantly better in patients treated with the triple-drug combination (p less than 0.05). However, no statistically significant differences in response to antibiotics at different infection sites or with regard to any single pathogen was found between the two groups. Trimethoprim/sulphamethoxazole seemed to be responsible for additional toxicity (nausea and vomiting) when added to amikacin plus piperacillin, but these side-effects were clearly related to the rate of infusion of trimethoprim/sulphamethoxazole. The findings of this study support the use of a three-drug versus a two-drug combination as empiric antibiotic regimen in febrile granulocytopenic patients.

Adolescent↗