Biomedical subjects

R F Meyer

Publications and source records attributed to R F Meyer.

At least 109 records · Page 6Linked to original sources

PubMed1977

Epithelial downgrowth following penetrating keratoplasty in the aphake.

Four of approximately 1,500 patients receiving corneal grafts developed epithelial downgrowth following penetrating keratoplasty. All were aphakic prior to grafting and had complicated postoperative courses. Epithelial proliferation over the iris and endothelium was demonstrated in three cases at the time of a repeat keratoplasty. While rare, this complication may occur more frequently than has been previously recognized.

Aged↗

PubMed1977

Effect of local antilymphocyte serum on antibody forming cells.

Locally administered antilymphocyte serum was irritating to the eye and failed to alter the production of antibody-forming cells in the homolateral lymph nodes, corneas, and uveal tracts of rabbits that had received intracorneal injections of bovine gamma globulin.

Animals↗

PubMed1977

Fungus implantation with wooden intraocular foreign bodies.

Four cases of wooden intraocular foreign bodies are presented. In each case the foreign body was found to be contaminated by fungi which may have contributed to the intraocular inflammatory response but did not actively invade ocular tissues. Tolerance of the eyes to the retained wooden material was very poor.

Adult↗

PubMed1976

Human leukocyte interferon for the prevention of recurrences of herpetic keratitis.

A double-blind clinical trial of human leukocyte interferon is in progress for assessment of the effect of this substance on recurrences of herpetic keratitis. Although human leukocyte interferon is highly effective in preventing infection in owl monkeys (protection from infection and prevention of recurrences correlate well in lower animals), there is no difference between the frequency of recurrences in placebo-treated patients and that in interferon-treated patients. Forty-nine patients have been treated with interferon, and 46 have received placebo; there have been seven recurrences (with herpes simplex virus isolated) in each group. The interferon used is highly stable both in storage in the laboratory and in clinical use. Because the titer of interferon in this study (6.4 X 10(4) units/ml) may be too low to accomplish our prophylactic needs, attempts are being made to use the material in more concentrated form.

Administration, Topical↗

PubMed1976

Phosphonoacetic acid in the treatment of experimental ocular herpes simplex infections.

Phosphonoacetic acid had a significant antiviral effect when applied topically, both in liquid and ointment preparations, on superficial herpetic keratitis in rabbits and was equally as effective as idoxuridine. It was also effective in the treatment of idoxuridine-resistant herpetic keratitis. Phosphonoacetic acid was not effective in the treatment of experimental herpetic iritis when applied topically but was significantly effective when administered intravenously and subconjunctivally. No significant local or systemic toxicity was encountered.

Acetates↗

PubMed1976

Scanning electron microscopy of postoperative M-K and moist chamber-stored corneas.

In the present study, using the in vivo test situation which all corneal donor material must meet, we performed penetrating keratoplastics utilizing corneal tissue stored for five days in either M-K medium or conventional moist chambers. Cat corneas stored for five days in M-K medium had a higher incidence of postoperative graft clarity along with an intact endothelial cell layer as determined by scanning electron microscopy than corneas stored in a conventional moist chamber. The endothelium of corneas immediately after moist chamber storage revealed minimal surface alteration which contrasted to the more severely stressed endothelium immediately after M-K storage. However, the M-K stored endothelium survived the trauma of penetrating keratoplasty much better than cells stored in moist chambers.

Animals↗

PubMed1976

The effect of splenectomy on corneal graft rejection.

Recent studies have suggested that the spleen may be essential for the "immunologic privilege" enjoyed by corneal grafts. We tested this hypothesis in rabbits by performing 38 exchange penetrating keratoplasties between 19 normal rabbits and 19 rabbits that had undergone splenectomy. No significant difference was found in the number of corneas rejected or the mean graft survival time between the normal and splenectomized rabbits.

Animals↗

PubMed1976

Improved corneal storage for penetrating keratoplasties in humans.

A group of 92 patients, who had penetrating keratoplasties with donor corneas that were stored for up to 7 days in M-K media, had 90% clear grafts 2 months postoperatively and about 80% at 6 months. A comparison of the postoperative corneal thickness measurements was made of the patients receiving donor corneas stored by cryopreservation for prolonged times in moist chambers for less than 24 hours, or in M-K media for several days. There was no statistical difference between the 3 storage methods during the 10 week follow-up nor was there any difference between 72 hours and 96 hours of storage in M-K media.

Adolescent↗

PubMed1975

Cardioselective beta-adrenergic blocking agents. 1. 1-((3,4-Dimethoxyphenethyl)amino)-3-aryloxy-2-propanols.

A series of 1-amino-3-aryloxy-2-propanols has been synthesized and examined for cardioselective beta-blockade. The introduction of the (3,4-dimethoxyphenethyl)amino group lead to the most cardioselective agents. Structure-activity relationships are discussed. Of the compounds tested 1-[(3,4-dimethoxyphenethyl)amino]-3-(m-tolyloxy)-2-propanol was selected for clinical trial because of optimal potency and selectivity.

Adrenergic beta-Antagonists↗

PubMed1975

Effect of local corticosteroids on antibody-forming cells in the eye and draining lymph nodes.

Significant numbers of antibody-forming cells (AFC) have been found in the cornea, uveal tract, and draining lymph nodes after the intracorneal injection of bovine gamma-globulin (BGG). To study the effect of locally administered corticosteroids on these antibody-forming tissues, we made unilateral intracorneal injections of rabbit eyes with BGG. These we followed immediately with subconjunctival injections of 10 mg. of triamcinolone suspension, and then with a second round of 10 mg. injections seven days later. A control group of animals received the BGG injections followed by two subconjunctival saline injections. We killed the animals on postinjection days 6, 9, 12, 15, and 21, and tested the draining lymph nodes, homolateral uveal tissue, and homolateral cornea for AFC by a modification of the Jerne placque technique. The local steroids had no effect on the number of AFC produced in the draining lymph nodes or on the circulating antibody response, but they reduced the number of AFC in the homolateral uveal tracts and corneas. Clinically there was less inflammatory response in the steroid-treated eyes than in the control eyes. The possible mechanisms by which corticosteroids achieve their anti-immunologic and anti-inflammatory benefits are discussed.

Animals↗

PubMed1975

Migration of a wooden foreign body into the lens: report of a case.

A penetrating ocular injury caused by a tree branch resulted in a small corneoscleral laceration that healed after primary repair. Post-traumatic inflammation persisted and a vitreous mass developed. The mass finally protruded through the pupil and touched the posterior cornea. Histologic examination of the enucleated eye showed that the lens had been replaced by a wooden foreign body that filled the pupillary space and was surrounded by lens capsule. No intact lens fibers remained.

Child↗

PubMed1975

Effect of pretreatment with local corticosteroids on antibody-forming cells in the eye and draining lymph nodes.

To study the effect of pretreatment of rabbits with locally administered steroids, unilateral subconjunctival injections of 10 mg. triamcinolone suspension were given 10 and 3 days before intracorneal injection of the same eye with bovine gamma globulin. We killed the rabbits 6, 9, 12, 15, and 21 days after the BGG injection, and determined the number of antibody-producing cells in the homolateral lymph nodes, corneas, and uveal tracts. Corticosteroids did not significantly affect the PFC response in the draining lymph nodes, but the number of plaque-forming cells in the corneas and uveal tracts was reduced. Steroid-treated eyes were less inflammed than control eyes. The possible mechanisms for the effect of steroids on the ocular immune response are discussed.

Adrenal Cortex Hormones↗

PubMed1974