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Biomedical subjects

R F Nigrelli

Publications and source records attributed to R F Nigrelli.

At least 19 recordsLinked to original sources
PubMed1978

Physiologically active substances from marine sponges V: Isolation of physiologically active compounds from the sponge Verongia archeri.

Methanolic extracts of hard and soft varieties of the sponge Verongia archeri were found to contain similar compounds. An isolation procedure and the structures of 2-(3',5'-dibromo-4'-hydroxyphenyl)-acetamide, 1-(3',5'-dibromo-1',6'-dihydroxy-4'-methoxycyclohexa-2',4'-diene)acetonitrile, and 2-oxo-5,7-dibromo-6-methoxy-9-hydroxy-8,9-dihydrocoumarin from one variety are described.

Animals↗
PubMed1976

Renin, cortisol and plasma volume in marine teleost fishes adapted to dilute media.

The renin-angiotensin system has been found in teleost fishes from both marine and fresh-water environments. In an attempt to define whether activity of the renin-angiotensin system is related to sodium balance in fishes, we transferred two euryhaline teleosts from seawater to hypo-osmotic media. Plasma renin activity decreased in American eels, Anguilla rostrata, after they were transferred from seawater to fresh water, and it did not change in the aglomerular toadfish, Opsanus tau, after transfer from 50% seawater to 5% seawater. Plasma sodium concentrations decreased significantly in toadfish in 5% seawater and in one group of eels in fresh water. Plasma levels of cortisol, a major mineralocorticoid in teleosts, and plasma volume, measured in eels, remained relatively constant. There are no clear correlations between plasma renin levels and those of plasma sodium or plasma cortisol. These results provide no evidence that the need of these fishes to conserve sodium when in hypo-osmotic media stimulates the renin-angiotensin system.

Adaptation, Physiological↗
PubMed1975

Multiple specificities of mammalian blood group substances comparatively studied with human isoagglutinins and fractionated anti-H lectins.

Purified blood group-active substances derived from different pig, horse, baboon, Rhesus monkey and human tissues were quantitatively studied for their haemagglutination inhibiting potency with: (1) human IgM anti-A and anti-B; (2) human anti-Lea and anti-Leb; (3) Ulex europaeus extracts separated into lectin fractions with respective L-fucose-inhibitable ('anti-HF') and chitobiose-cellobiose-inhibitable ('anti-HC') combining sites. Irrespective of species origin, A and B blood group activity per milligram of purified material tended to be strikingly higher in substances low in, or devoid of, Lewis blood group activity. Most of the blood group substances displayed variable but about equally balanced amounts of Ulex anti-HF and anti-HC inhibiting activity. In contrast, pig submaxillary gland mucins displayed strikingly high levels of Ulex anti-HC inihibiting activity, even in the complete absence of Ulex anti-HF inhibiting activity. These serological findings are consistent with current biochemical concepts regarding the heterosaccharide microheterogeneity of blood group-active glycoproteins.

ABO Blood-Group System↗
PubMed1970

Cell cultures from marine mammals.

Cell cultures grown from the gray seal Halichoerus grypus and the dolphin Lagenorhynchus obliquidens support the replication of several human viruses. Further evidence indicates the gray seal kidney cell culture has transformed.

Animals↗