PubMed Health⌕ Search

Biomedical subjects

R F Roddam

Publications and source records attributed to R F Roddam.

12 recordsLinked to original sources
PubMed1994

Thyroid function screening in newly admitted psychiatric inpatients.

Thyroid function tests (T4, T3RU, free thyroxine index) were performed upon admission in 269 acute psychiatric patients during a 2-year period. Thyroid disease was detected in 3% and euthyroid abnormalities in 9.3%. T4 and free thyroxine index were significantly lower in depressed patients than those with mania or schizophrenia. The rate of abnormal thyroid tests was lower in this study than in previously reported surveys of psychiatric admissions. Laboratory techniques or differences in population may be responsible for the difference. The differences in thyroid function test values between psychiatric diagnoses are relatively new findings, and appear worthy of investigation.

Adult↗
PubMed1982

Hypoglycemia associated with antibodies to the insulin receptor.

Antibodies to the insulin receptor are insulinomimetic in vitro, although they generally induce insulin resistance in vivo. We report the novel case of a patient who presented with fasting hypoglycemia as the sole manifestation of autoantibodies to the insulin receptor. Prednisone therapy (120 mg per day) produced a rise in fasting glucose to more than 100 mg per deciliter (6 mmol per liter) within 48 hours, although there was no detectable change in the titer of antireceptor antibodies. After 10 weeks of therapy, the titer of antireceptor antibodies had fallen approximately 100-fold, and prednisone could be discontinued without recurrence of hypoglycemia. This case demonstrates that antireceptor antibodies must be considered in the differential diagnosis of hypoglycemia, especially in patients with other manifestations of autoimmunity.

Adipose Tissue↗
PubMed1982

Mixed meal tolerance test and reactive hypoglycemia.

Twenty-six patients with symptoms suggestive of postprandial hypoglycemia were investigated by oral glucose tolerance test (OGTT). During the OGTT, symptomatic hypoglycemia occurred in 10 (38.5%). Nine of these 10 sugjects were given mixed meal tolerance tests (MMTT) and symptomatic hypoglycemia failed to occur in any case. During the OGTT the nadir glucose was significantly lower than that during MMTT (44.1 +/- 1.5 vs. 77.3 +/- 4.8 mg/dl +/- SEM, respectively; p less than 0.0005). Serum insulin during MMTT peaked significantly earlier than during OGTT (46.7 +/- 7.3 vs. 86.7 +/- 11.7 minutes (SEM, respectively; p less than 0.0125). The early secretion of insulin during MMTT may explain the lack of symptomatic hypoglycemia in these patients. We conclude that reactive hypoglycemia, when tested by a more natural stimulus (such as mixed meal) rather than by OGTT, is uncommon.

Adolescent↗
PubMed1977

Hyperinsulinemic hypoglycemia: effect of epinephrine suppression.

The inhibitory effect of epinephrine on basal and tolbutamide-stimulated insulin release was studied in 5 patients with hyperinsulinemic hypoglycemia. Epinephrine inhibited both basal and tolbutamide-induced insulin release in patients with beta-cell adenoma and hyperplasia, but failed to inhibit insulin release in a patient with beta-cell carcinoma. The inhibition of basal insulin with epinephrine was maximum in patients with beta-cell hyperplasia. This differential inhibitory effect of epinephrine on insulin release may prove to be a useful screening test in the preoperative diagnosis of the nature of the lesion producing hyperinsulinemia.

Adenoma↗