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R F Sewell

Publications and source records attributed to R F Sewell.

9 recordsLinked to original sources
PubMed1995

Method for calculation of probability of matching a bounded regular expression in a random data string.

A method is presented for determining within strict bounds the probability of matching a regular expression with a match start point in a given section of a random data string. The method in general requires time and space exponential in the number of optional characters in the regular expression, but in practice was used to determine bounds for probabilities of matching all the ProSite patterns without difficulty.

Algorithms↗
PubMed1989

Human mononuclear cells contain an endoglycosidase specific for heparan sulphate glycosaminoglycan demonstrable with the use of a specific solid-phase metabolically radiolabelled substrate.

Xyloside-initiated 35SO4(2-)-labelled glycosaminoglycans were isolated from the medium of cultured bovine glomeruli and covalently coupled to Sepharose 4B to construct a solid-phase substrate suitable for the detection of endoglycosidases. The substrate is rendered specific for heparitinase by prior digestion with chondroitin sulphate ABC lyase and is insensitive to proteinase, neuraminidase and hyaluronidase. Normal human mononuclear cells are shown to contain a heparitinase. This enzyme appears to be cell-associated and can be partially purified from human spleen by heparin affinity chromatography.

Animals↗