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Biomedical subjects

R F Smart

Publications and source records attributed to R F Smart.

5 recordsLinked to original sources
PubMed1991

Polytef paste for urinary incontinence.

A series of 28 patients injected with polytetrafluoroethylene (PTFE) (Polytef, Mentor) paste for urinary incontinence is presented. The cystoscopic method of injection was used in 25 patients. Twenty-four adult females with stress incontinence were treated: 10 of these were long-term cures and five improved. Success rates were higher in those who had had previous gynaecological surgery (10 of 12: P less than 0.05) or who had well supported vaginal walls (5 of 5: P less than 0.05). Three adult males were treated, but all failed. Complications including the risk of micro-embolization are discussed. Low morbidity is an attraction and it is concluded that this treatment may have a place for older women with stress incontinence and a well-supported, preferably scarred, anterior vaginal wall. It may be performed under topical local anaesthetic if desired. The availability of a more suitable agent would widen the application of the technique. Subject to long-term experience vindicating early trials, glutaraldehyde cross-linked collagen may be a suitable replacement for PTFE in this role.

Adult↗
PubMed1979

Radical radiotherapy for carcinoma of the prostate.

The results of treatment of carcinoma of the prostate with radical radiotherapy are presented. The principal aim has been to attempt cure, and only those free of secondary involvement have been irradiated. A total tumour dose of approximately 6000 rad has been administered to localised field encompassing the prostate. The treatment has been well tolerated. Our series of 42 patients was followed from one to eight years and the results are encouraging.

Follow-Up Studies↗
PubMed1978

Intramural oesophageal haematoma complicating anticoagulant therapy.

A case of intramural oesophageal haematoma complicating anticoagulant therapy is described. Severe chest pain and complete obstruction of the oesophagus resulted. Early fibreoptic endoscopy facilitated the diagnosis. The condition resolved spontaneously with conservative management. A similar case has not been previously reported.

Aged↗
PubMed1976

Severe pseudomembranous colitis after lincomycin and clindamycin.

Four cases of severe pseudomembranous colitis following the use of lincomycin and clindamycin are described; 2 required emergency total colectomy and 2 died. Cases of such gravity after the use of these drugs have not been previously reported. On hundred and fifty-six orthopaedic cases where clindamycin and lincomycin were used postoperatively are reviewed; 34 had diarrhoea (22 per cent), and 3 of the severe cases occurred in this group. The diagnosis of pseudomembranous colitis may be difficult as the latent period from initiation of drug therapy to commencement of diarrhoea may be as much as 18 days, and that from cessation of drug therapy may be as much as 11 days. The value of early sigmoidoscopy in cases of diarrhoea of obscure aetiology is emphasized, and the characteristic sigmoidoscopic and histological appearances of pseudomembranous colitis are described. As these drugs may produce a lethal condition it is suggested that they should be used with appropriate discretion, especially in the elderly female who appears to be most at risk.

Aged↗