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R F Spaide

Publications and source records attributed to R F Spaide.

59 records · Page 4Linked to original sources
PubMed1987

Ocular findings in cystic fibrosis.

We examined 32 patients with cystic fibrosis, paying special attention to optic nerve performance and pupillary function. Decreased visual acuity occurred in nine of 64 eyes. Three of 17 patients (18%) who used chloramphenicol had bilaterally delayed P100 waves of the visual-evoked response of greater than 3 standard deviations. This was not found in patients who did not use chloramphenicol. Contrast sensitivity in patients with cystic fibrosis was decreased at every spatial frequency when compared to healthy controls. This decrease was noted in patients who did and did not use chloramphenicol, suggesting that chloramphenicol is not the only cause of decreased contrast sensitivity in cystic fibrosis. With pharmacologic pupil testing we determined that patients with cystic fibrosis display a preganglionic oculosympathetic paresis that corresponded to the disease severity, as measured by the Shwachman score.

Adolescent↗
PubMed1987

Shaken baby syndrome. Ocular and computed tomographic findings.

Violent shaking of young infants has a variety of ocular and systemic sequelae, including retinal and subdural hemorrhages, seizures, coma, and death. The syndrome can be difficult to recognize because of the lack of external signs. The retinal examination and computed tomographic findings are absolutely essential for making the diagnosis, but very little information is available concerning this disorder in the ophthalmology literature. This paper presents the findings of a case of shaken baby syndrome and discusses the challenges in diagnosis.

Battered Child Syndrome↗
PubMedDate not supplied

Risk factors for choroidal neovascularization in young patients: a case-control study.

A pair-matched, case-control design was used to study exposure to Histoplasma capsulatum and other environmental factors, and to determine various host characteristics including human leukocyte antigen (HLA) typings in 94 young patients with macular choroidal neovascularization (CNV) and in 94 controls with other eye diseases. Patients with two types of retinal patterns were studied: Type I, or those with CNV with one or no chorioretinal atrophic spots in the posterior pole or periphery (n = 51), and Type II, or those with CNV and 2 or more chorioretinal atrophic spots (n = 43). Our purpose was to explore whether these two variants of idiopathic CNV have different and distinguishable epidemiologies which may or may not be related to prior exposure to Histoplasma. We found that histoplasmin skin tests were negative in all but two Type I cases. The combination of the HLA-B7 and HLA-DR2 markers (but not either marker alone) was significantly increased in Type I cases. Among Type II cases, HLA-B7, HLA-DR2, HLA-DQ1, a positive histoplasmin skin test, myopic refractive error, prior residence in a histoplasmosis endemic area, occupations involving exposure to animals, and hypertension were all significantly increased. Histoplasmin skin test responses were positive in 18 Type II cases (45%). In the multivariate analysis, only DR2 and the combined presence of DQ1 and a positive histoplasmin skin test remained predictive of Type II disease. Our findings suggest that histoplasmin sensitivity is associated with some, but not all, cases of Type II disease. However, histoplasmin sensitivity appears to have no relationship to Type I disease. HLA factors may play a role in both disease types, possibly by producing a modified immune response to Histoplasma and/or other unidentified agents.

Adolescent↗
PubMedDate not supplied

Spasmus nutans as a presenting sign of an arachnoid cyst.

Spasmus nutans, usually believed to be a benign entity, is a disorder of young children consisting of nystagmus, head nodding and an anomalous head position of unknown etiology. We present a patient with spasmus nutans who proved to have a large arachnoid cyst. When the cyst was shunted the nystagmus lessened. Recent studies suggest that the head nodding and anomalous head position are adaptive mechanisms that compensate for the nystagmus and not pathological in themselves. Therefore, spasmus nutans is not a triad of findings, but an acquired nystagmus with associated adaptive responses. Because spasmus nutans implies a benign entity composed of three requisite components, we feel it is an inaccurate term that should be abandoned. A better designation would be acquired nystagmus of infancy, which would not imply a benign etiology.

Arachnoid↗