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Biomedical subjects

R Ferrando

Publications and source records attributed to R Ferrando.

At least 37 records · Page 2Linked to original sources
PubMed1981

[Transfer of vitamin A to the egg influenced by bacitracin or flavomycin (author's transl)].

During two experiments hens are fed with diet supplemented with or without 10 ppm of Bacitracin or 0,5 ppm of Flavomycin. Both increase retinol transfer from diet to yolk. Differences are not always significant. They are concerning almost a more important percentage of eggs whose yolks contain between 500 and more than 700 IU of vitamin A (66,6 p. 100 for Bacitracin supplement; 80,9 p. 100 for Flavomycin supplement and 45 p. 100 for control). Each additive increases hepatic storage and serum level of retinol but not significantly. Transfer of vitamin A from diet to yolk is between 12,1 p. 100 and 24,0 p. 100 regarding individual variations. There is no influence from the strain. Warren or Dekalb, used.

Animals↗
PubMed1979

[Vitamin A consumption in pregnant and non pregnant rats, and in castrated rats receiving or not receiving estradiol or pregnenolone; relation to tocopherol and cytochrome P-450].

Consumption of vitamin A and cytochrome P 450 by pregnant Rat is more important than in non pregnant and ovariectomised Rat. Estradiol implant in ovariectomised female has some, but slighter, influence only on retinol. These physiological situations have no action on the hepatic levels of tocopherols (total and alpha). These results are discussed.

Animals↗
PubMed1979

Metabolic changes in red blood cells in malignant lymphomas.

Serum copper levels (SCL) which are concomitantly related to red blood cell free copper are significantly increased in some malignant lymphomas in the phase of activity. This results in a profound inhibition of red cell key glycolytic enzymes, hexokinase (Hx) being the most sensitive. Fifteen patients (eight with Hodgkin's disease and seven with non-Hodgkin's lymphoma) were studied for serum and red cell copper concentrations and Hx activity. The mean red cell life span was determined using 51Cr labelled red cells. The resulting data shows that in active disease an increase in SCL was associated with a decrease in Hx activity and a shortened red cell survival. In these cases there was no evidence of autoimmune phenomena or of direct bone marrow involvement by the disease. It is suggested that the increase in copper levels results in a shortened red cell life span through a copper-induced inhibition of red cell Hx.

Copper↗
PubMed1978

[Induction of cytochrome P 450 by phenobarbital in cats].

Phenobarbital administration to the Cat an animal hypersensitive to the actions of many toxic substances or to physiological compounds such as hormones, does not produce cytochrome P 450 induction. Consequently, hepatic storage of retinol remains unchanged. The specific and original characteristics of the Cat in this field are underlined by these results.

Animals↗
PubMed1978

[Toxicity by relay. III. Safety for the human consumer of the use of Carbadox, a feed additive for swine, as estimated by a 7 years relay toxicity on dogs].

To check the possible toxicity risks of the meat from swine fed with a residue producing feed additive: Carbadox, a new methodology was used. It is the "Relay Toxicity". Swine were fed with a high dose of the additive and sacrificed without any withdrawal. In such conditions meat contains a high level of residues. The frozen meat was given daily--after thawing--at 100 g or 200 g/dog to 12 beagle dogs, 6 females and 6 males, sacrificed when 87.5 months old (85 months on experiment). On these animals, no anomaly was found: on weight gain and health; on fertility and reproductive performances; on hematology and biochemical values of blood and urine; and after careful macroscopic or microscopic examinations of the animals at safrice. We were able to obtain a safety factor above 9000 when Carbadox is used at the maximum level approved 50 ppm, and the withdrawal 4 weeks before slaughtering. To conclude, the absence of anomaly allows us to confirm the safety for the human consumer when Carbadox is used as a feed additive for swine.

Animals↗