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Biomedical subjects

R Filly

Publications and source records attributed to R Filly.

18 recordsLinked to original sources

The California Maternal Serum alpha-Fetoprotein Screening Program: the role of ultrasonography in the detection of spina bifida.

Between January 1988 and June 1990, 161 cases of open spina bifida were identified by the California Maternal Serum alpha-Fetoprotein Screening Program. Eight percent of these cases were not diagnosed by an initial ultrasonographic evaluation. Three defects were not recognized until birth. Ultrasonography is inadequate to identify all cases of open spina bifida.

California↗

Selective termination of multiple gestations.

Twenty-two selective terminations in multiple gestations were performed by a number of different methods. In 17 dichorionic pregnancies there was a successful delivery in surviving singletons or twins. In five monochorionic pregnancies undergoing selective termination there was a successful delivery in only one and a pregnancy loss in the other four. Six of the 18 delivered pregnancies were complicated by premature labor and delivery. Among the several methods used for selective termination, intracardiac potassium chloride injection appears to be the procedure of choice in dichorionic pregnancies.

Abortion, Induced↗

Sonographic monitoring of hepatic cryosurgery in an experimental animal model.

Several cryosurgical techniques for freezing hepatic parenchyma have been developed. To assess the efficacy of sonographic monitoring of hepatic cryosurgery, an experimental animal model was devised. Real-time sonography was used to monitor the in vivo evolution of hypothermically induced hepatic cryolesions in four mongrel dogs. The results suggest that sonography is an effective and accurate means of monitoring the entire freezing and thawing cycle in hepatic cryosurgery.

Animals↗

Prenatal diagnosis of asphyxiating thoracic dysplasia.

A fetus at risk for asphyxiating thoracic dysplasia was studied with ultrasound examination at 16, 18, and 23 weeks of pregnancy. Definite shortness of fetal femora was observed. Radiographic and histologic examinations after pregnancy termination confirmed the diagnosis. Asphyxiating thoracic dysplasia appears to be one of an increasing number of skeletal dysplasias that can be diagnosed prenatally with ultrasound.

Asphyxia Neonatorum↗

[Role of echography in the diagnosis of extra-uterine pregnancy. Value of the double sac sign].

Ultrasound images showing normal intrauterine pregnancy with embryo practically excludes the presence of an extrauterine pregnancy (E.U.P.). The efficacy of the double sac sign in establishing, almost definitely, a normally implanted pregnancy makes it important for this sign to be recognized. In other cases (absence of double sac sign, empty uterus with or without an associated fluid mass in the cul de sac) the risk of an E.U.P. varies and more aggressive exploratory methods are necessary to confirm the diagnosis.

Chorionic Gonadotropin↗

Absence of an effect of diagnostic ultrasound on sister-chromatid exchange induction in human lymphocytes in vitro.

The frequency of sister-chromatid exchanges in human lymphocytes cultured in vitro was not changed after a 30-min exposure to a 2 MHz focused, diagnostic ultrasound beam with a pulse repetition rate of 1000 Hz, 1 musec burst duration, 100 W/cm2 temporal peak, spatial peak intensity. These results are consistent with those obtained with a number of other cell types and are contrary to some previously reported effects for human lymphocytes.

Bromodeoxyuridine↗

Sludge is calcium bilirubinate associated with bile stasis.

Biliary sludge is a frequent finding on abdominal sonography. It is most often found after prolonged stasis of gallbladder bile associated with other illness or mechanical obstruction of the common duct, and seldom indicates primary gallbladder disease. In most cases, sludge is a suspension of pigment precipitates in bile, and is at least in part calcium bilirubinate. Sludge may disappear with the return of normal gallbladder contractility. The ease with which this precipitate forms during stasis of gallbladder bile suggests a role for this process in the pathogenesis of cholelithiasis.

Bile↗

Posterior urethral valves.

During the past decade some urologists and radiologists have doubted the existence of posterior urethral valves. It has been suggested that the primary lesion in patients thought to have urethral valves is bladder neck obstruction. During the past seven years we have seen an average of three new cases of posterior urethral valves per annum. In all cases the valves themselves, not the bladder neck, obstructed the urethra. The urologist may miss valves at urethroscopy, but use of the new fibreoptic endoscope has improved his chances of seeing them. Posterior urethral valves may not be demonstrated radiologically if the radiologist does not use a rapid recording device or if the patient does not micturate forcefully during micturating cystourethrography. Failure to detect the valves may lead to an erroneous diagnosis of bladder neck obstruction.

Adolescent↗

Routine full-lung tomography in the initial staging and treatment planning of patients with Hodgkin's disease and non-Hodgkin's lymphoma.

The yield of additional information from anteroposterior full-lung tomograms that changed stage or treatment, in comparison to that obtained from routine chest radiographs, was prospectively evaluated in 243 previously untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma. Although new information was found in 21.4% of all patients, in only 1.2% did these additional data change patient staging. In 3.3% of the other patients the tomograms provided information that affected radiotherapy treatment planning as practiced in our institution.

Adult↗

Radiographic distribution of intrathoracic disease in previously untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma.

An analysis was made of the incidence of various intrathoracic abnormalities noted on plain chest radiographs and tomograms in a consecutive series of 300 patients with untreated Hodgkin's disease and nonHodgkin's lymphoma. Those with Hodgkin's disease have a higher incidence of intrathoracic disease at presentation than those with non-Hodgkin's lymphoma (67% vs. 43%). Bulky superior mediastinal lymphadenopathy is the hallmark of Hodgkin's disease. Lung involvement was more common in Hodgkin's disease (11.6% vs. 3.7%) and was always accompanied by mediastinal and/or hilar lymphadenopathy.

Bone Neoplasms↗