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R Fowler

Publications and source records attributed to R Fowler.

69 records · Page 4Linked to original sources

Determination of the distribution of cannabinoids in cannabis resin using high performance liquid chromatography.

A high performance liquid chromatographic system is described for the separation of cannabinoids, which were detected by ultra-violet absorption at 220 nm. The identity of the cannabinoids was established by comparison of retention times with reference compounds, by simple chemical conversions to other known cannabinoids, and by mass spectrometry after isolation by preparative chromatography. Cannabis resin from Pakistan and Lebanon was examined for the presence of these cannabinoids. A study of the uniformity of distribution of cannabinoids in individual resin slabs was made by taking a total of 68 samples from 4 different slabs. The variations in cannabinoid content between slabs was measured by 85 different slabs. The validity of these measurements, to determine a common origin of resin for forensic purposes, was tested using resin obtained from 94 different law enforcement seizures.

Cannabinoids

11 November 1979--a day to remember: the Mississauga disaster.

The derailment of a train carrying potentially lethal chlorine, accompanied by exploding tank cars of propane, set into motion the evacuation of the Mississauga Hospital, Queensway General Hospital (Etoblcoke), and Oakville-Trafalgar Memorial Hospital, near Toronto. The method in which the three hospitals, along with the 220,000 residents of Mississauga, were evacuated was so highly efficient and orderly that many now question the necessity of the action. But absence of panic should not be interpreted as an absence of danger. The Economist (17 - 23 November, 1979, volume 273, number 7107) extrapolated data from a British study to show there was enough chlorine in the tank to kill 24,000 people, given the population density in the area of the derailment. The purpose of this article is to describe the involvement of hospital pharmacy in the "Mississauga Saga", and to draw some conclusions from this experience.

Disasters