PubMed Health⌕ Search

Biomedical subjects

R Fu

Publications and source records attributed to R Fu.

59 records · Page 4Linked to original sources
PubMed1992

Glutathione and antioxidant enzymes in skeletal muscle: effects of fiber type and exercise intensity.

Glutathione status and antioxidant enzymes in various types of rat skeletal muscle were studied after an acute bout of exercise (Ex) at different intensities. Glutathione (GSH) and glutathione disulfide (GSSG) concentrations were the highest in soleus (SO) muscle, followed by those in deep (DVL) and then superficial (SVL) portions of vastus lateralis. In DVL, but not in SO or SVL, muscle GSH increased proportionally with Ex intensity and reached 1.8 +/- 0.08 mumol/g wet wt compared with 1.5 +/- 0.03 (P < 0.05) in resting controls (R). GSSG in DVL was increased from 0.10 +/- 0.01 mumol/g wet wt in R to 0.14 +/- 0.01 (P < 0.05) after Ex. Total glutathione (GSH + GSSG) contents in DVL were also significantly elevated with Ex, whereas GSH/GSSG ratio was unchanged. Activities of GSH peroxidase (GPX), GSSG reductase (GR), and catalase (CAT) were significantly higher in SO than in DVL and SVL, but there was no difference in superoxide dismutase activity between the three muscle types. Furthermore, Ex at moderate intensities elicited significant increases in GPX, GR, and CAT activities in DVL muscle. None of the antioxidant enzymes was affected by exercise in SO. It is concluded that rat DVL muscle is particularly vulnerable to exercise-induced free radical damage and that a disturbance of muscle GSH status is indicative of an oxidative stress.

Animals↗
PubMed1980

Motor nerve latencies through the tarsal tunnel in normal adult subjects: standard determinations corrected for temperature and distance.

A standardized method of obtaining distal motor latencies of the medial and lateral plantar nerves over fixed distances with temperature correction in 37 normal subjects is presented. The posterior tibial nerve was supramaximally stimulated 6, 8, 10, 12 and 14cm proximal to the active electrode over the motor point of the abductor hallucis. These same stimulation points were then used when recording from the abductor digiti minimi. Distance was measured with both flexible tape and calipers. Surface skin temperature was recorded at 3 different skin sites on the foot. Distal motor latency for the medial plantar nerve using a flexible tape with no temperature correction for an 8cm segment was 3.4 +/- SD 0.5msec and 3.8 +/- 0.5msec for a 10cm segment. With the same 8cm stimulation point, a flexible tape, but no temperature correction, the lateral plantar nerve distal motor latencies were 3.6 +/- SD 0.5; for the 10cm point, they were 3.9 +/- SD 0.5. Nontemperature corrected data for 6, 12, and 14cm segments using both calipers and flexible tape are presented, as are the data from 8 and 10cm segments of both the medial and lateral plantar nerves with temperature correction between 28 and 32C. These standard vales allow more accurate assessment of the tarsal tunnel syndrome (TTS). A case of bilateral tarsal tunnel is included. It is noted that early changes in TTS may not be relfected in prolonged latency measurements, and that the emg may be a more sensitive indicator of the process. Both latencies and emgs are used for the diagnosis.

Adult↗