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Biomedical subjects

R Fuchs

Publications and source records attributed to R Fuchs.

At least 199 records · Page 11Linked to original sources
PubMed1980

[Staging of morbus Hodgkin by explorative laparotomy (author's transl)].

75 patients suffering from Hodgkin's disease underwent explorative laparotomy. This meant to correct the initial staging in a percentage of 34. There was an increase of postoperative complications in secondary laparotomies. In 4 our of 25 patients an unexpected involvement of the spleen could be demonstrated.

Adolescent↗
PubMed1979

[Acute mature myelocytic leukemia as a form of the myeloproliferative syndrome].

On the basis of five observations of adult patients with the clinical feature of mature cellular leukaemia which proved to be therapy-refractory and which was characterized by a rapid course is referred to the necessity of the differentiation of such cases from the classical myeloic leukaemia. The cardinal symptoms of this type of disease, which probably is identified with the cases described in literature as atypical chronic myelosis, as paraneutrophil leukaemia or as acute myelofibrosis, and also shows common features with the juvenile chronic myelosis, are, apart from the mature cellular differential blood picture a short life expectancy (less than 1 year), an initial thrombocytopenia, a normal or increased activity of the alkaline granulocyte phosphatase, the lack of Ph1-chromosome as well as the bad therapeutic reaction to busulfan. The observation of the simultaneously existing fibroses of the bone marrow as well as of the final increase of immature blasts induced the classification of the clinical picture as a special form of the myeloproliferative syndrome.

Acute Disease↗
PubMed1979

[Experiences with primary and secondary laparotomy with splenectomy in Hodgkin's disease].

The explorative laparotomy with splenectomy belongs under adequately strong indication to the standard techniques of the dilated diagnostics and stage subdivision of lymphogranulomatosis. 61 patients of the Medical Academy Magdeburg were exploratively laparotomised from 1974--1978, of them 38 patients primarily before the beginning of the therapy and 23 patients secondarily 1--8 years after therapy. Changes of the stages before and after laparotomy, relations between affection of the spleen and histological type and primary histology, respectively, as well as weight of the spleen are discussed, postoperative complications are explained and adequate conclusions rendered.

Diagnostic Techniques, Surgical↗
PubMed1979

[Therapy of malignant non-Hodgkin's lymphoma].

Up to now the results of the therapy of malignant non-Hodgkin lymphomas are not satisfactory. In order to improve these results decisively it is necessary to develop and to test therapeutic strategies on standardised diagnostic basis. On the basis of the histological classification after Kiel of the malignant non-Hodgkin lymphomas and the clinical stage subdivision of the lympho-granulomatosis after Rye (for the malignant non-Hodgkin lymphomas modified by Musshoff) in the present paper therapeutic recommendations are given which are based on proved therapeutic regimes.

Brain Neoplasms↗
PubMed1979

Human tonsil lymphocytes in the transfer of cell-mediated immunity.

Peripheral blood lymphocytes have the ability to transfer cellular immunity. In this study, we investigated whether human tonsil lymphocytes could transfer cellular immunity. Human tonsil lymphocyte ultrafiltrates, after separation through gel filtration, showed five fractions in Sephadex-G-10, as well as four in Sephadex-G-25,4. The extracts and the fractions have characteristic biochemical as well as biological properties. The biological activity of ultrafiltrates from human tonsil lymphocytes was compared with the activity of ultrafiltrates prepared from human peripheral blood lymphocytes, for identification studies of a 'Transfer Factor' from human tonsils. Ultrafiltrates prepared from human peripheral blood lymphocytes (Ascher et al., 1976) and tested, showed similar biochemical and biological properties.

Humans↗
PubMed1978

Metabolism, oxygen transport, and erythropoietin synthesis in the anemia of thermal injury.

The relationship between metabolism, oxygen transport, and anemia was assessed in burn patients. A significant negative correlation was found between erythrocyte 2,3 DPG, the major modulator of oxygen transport, and erythropoietin synthesis. Simultaneous bioassay and radioimmunoassay for erythropoietin revealed elevated values in the anemic burn patients. Elevated 2,3 DPG values during convalescence from thermal injury may remove the "anemic hypoxia" stimulus to erythropoieitn production, resulting in persistence of the anemia.

Adult↗
PubMed1978

[Method for the stabilization of E-rosettes with glutaraldehyde].

A technically simple method of fixing E-rosettes is represented. Under the influence of glutaraldehyde of 0.5% the E-rosettes being themselves very fragile assume a solid form and may be firmly spread to smears. Comparative examinations made on fresh and panoptically stained preparations showed a good accordance of results. The advantages of this method consist in its easy handling, possible simultaneous or alternative application of two counting procedures and the possibility of having the test results registered in archives.

Aldehydes↗
PubMed1977

[Studies on cell-mediated immunity in patients with chronic lymphatic leukemia].

More than 100,000 variables (anamnestic, clinical, serological, radiological and histological individual findings) of 142 patients with rheumatoid arthritis underwent a factor analysis. In the calculatory statistical course by means of information densification we established a few basic variables, called factors. The interpretation of these factors showed apart from logical and pathogenetic connection also relations which gave an impetus for further clinical research.

Aged↗
PubMed1977

The association of elevated plasma cortisol and early atherosclerosis as demonstrated by coronary angiography.

To study the association of plasma cortisol and coronary atherosclerosis, we elected 71 male outpatients who had coronary angiography as part of their evaluation at our facility. Forty-eight percent of the angiograms showed no evidence of coronary artery disease (CAD), 20% showed mild CAD, and 32% showed moderate to severe CAD. We found significant correlations between elevated serial morning plasma cortisols and moderate to severe coronary atherosclerosis. Using the odds ratio, we compared plasma cortisol to the major risk factors for coronary artery disease. Plasma cortisol was second only to serum cholesterol as a discriminator in our patient population between diseased and non-diseased patients. We found a significant correlation between plasma cortisol and cholesterol, blood pressure, and smoking- the three cardinal risk factors for CAD. The highest degree of correlation was found between cortisol and cholesterol. The possible significance of the association of cortisol and the major risk factors for CAD is discussed.

Adult↗