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Biomedical subjects

R G Baxter

Publications and source records attributed to R G Baxter.

6 recordsLinked to original sources
PubMed1997

Comparative analysis of nitric oxide synthase immunoreactivity in the sacral spinal cord of the cat, macaque and human.

Nitric oxide synthase immunoreactivity (bNOS-ir) was examined in the sacral spinal cord of the cat, macaque monkey and human using an antibody to the c-terminal region of neuronal NOS. In S2 of all 3 species NOS-ir was identified in both dorsal and ventral horns. In cat, monkey and human, bNOS-r occurred in sensory neurons of superficial laminae and the base of the dorsal horn, in autonomic neurons around the central canal and in the intermediolateral sacral spinal nucleus. In all 3 species, a large proportion of somatic motor nuclei in the ventromedial (VM), ventrolateral (VL) nuclei, and Onuf's nucleus (ON) showed high bNOS-ir, while others exhibited markedly lower immunoreactivity. Validatory experiments showed separate cellular localisation for bNOS, inducible NOS (iNOS), and endothelial NOS (eNOS) with only bNOS being localised to neuronal perikarya. Comparative morphometric analyses of the relative proportions and diameters of motor neurons in the VL, VM and ON exhibiting high and low levels of bNOS-ir revealed statistically significant differences in proportions in individual nuclei, and differences in size were generally not statistically significant. Finally, a comparison between cat sacral and thoracic spinal cord showed bNOS-ir in motor neurons of S2 was subject to less animal and rostrocaudal segment variation than in T10.

Anal Canal↗
PubMed1992

Current status of general practice research in Australia. Analysis of a national database.

OBJECTIVE: To describe the current status of general practice research activity in Australia. DESIGN: A descriptive survey of research projects included in a national research database, established by the Royal Australian College of General Practitioners. The study instrument was a mailed questionnaire. SETTING AND PARTICIPANTS: Research projects involving or directly related to general practice that had commenced in Australia since 1 January 1989. Responses were specifically sought from all universities, the Family Medicine Programme and the Royal Australian College of General Practitioners. RESULTS: Two hundred and thirty-seven projects from 130 different principal investigators, one-third of whom were not medical practitioners, were analysed. Over 85% of research took place in association with a recognised tertiary institution. Over half of the projects were descriptive only; the most common areas were medical education, prevention and screening and health services research. Of the 69 projects completed prior to 1991, 49 had been submitted for publication and 26 had been accepted. CONCLUSIONS: The amount of general practice research undertaken in Australia is still small in relation to the size of the workforce, and most are descriptive studies. This national database will enable longitudinal changes in such patterns to be effectively monitored.

Australia↗
PubMed1992

Diabetes in an elderly population. A controlled study of morbidity and outcomes.

OBJECTIVE: To determine in an elderly diabetic population the frequency of vascular and related disorders, the mortality, and outcomes compared with a matched control group. SETTING: The Queen Elizabeth Geriatric Centre, Ballarat, Victoria. METHOD: The medical records of all diabetics admitted between 1982 and 1987 inclusive, and a control group matched for age, sex and ward of admission were studied retrospectively. The presence of associated conditions and outcome parameters were entered in to a database and analysed statistically. RESULTS: Increased prevalence in individuals with diabetes of ischaemic heart disease (2.0:1.0), cerebrovascualr accident (1.9:1.0) and hypertension (1.5:1.0). Similar death rate, cumulative bed days, discharge destination and use of discharge services. CONCLUSION: Despite the more frequent presence of clinical vascular disease, an elderly population with diabetes had the same outcomes as matched controls and did not require more bed occupancy or use of community based services.

Aged↗
PubMed1992

An analysis of funding for general practice research in Australia.

OBJECTIVE: To describe the current status of funding for general practice research in Australia. DESIGN: A descriptive survey analysing funding arrangements of research projects included in a national research database, established by the Royal Australian College of General Practitioners. SETTING AND PARTICIPANTS: Research projects involving, or directly related to, general practice that had commenced in Australia since 1 January, 1989. Responses were specifically sought from all universities, the Family Medicine Programme and the Royal Australian College of General Practitioners. MAIN OUTCOME MEASURES: Extent and source(s) of funding received or requested, or both; relationship of funding received to the following: qualification and affiliations of the principal investigator; submission of the research project towards a higher degree; subject area(s) covered by the research; study design method used; and duration of project. RESULTS: A total of 237 projects from 130 principal investigators were included in the analysis. Of these, 149 (63%) had been submitted for funding and 98 (66%) had been successful. The amount of funding ranged between $300 and $855,600. The most common source of funding was the General Practice Evaluation Programme. Research contributing towards a higher degree was associated with successfully receiving funding. Other variables, including the study design and study area, were not significantly associated with an increased success of funding. CONCLUSIONS: The total amount of funds spent on general practice research is still small, relative to the size of the workforce. However, over half of general practice research undertaken in Australia is not submitted for funding. Of the research that is submitted, the success rate of receiving funds is high.

Australia↗
PubMed1975

Down syndrome and thyroid function in adults.

Thyroid function has been studied in 11 middle-aged and elderly subjects with proven Down syndrome. Unequivaocal biochemical evidence of hypothyroidism was found in 6, and of thyrotoxicosis in 1. It is concluded that, in contrast to the situation in children with Down syndrome, thyroid dysfunction is exceedingly common in adults with the syndrome.

Adult↗