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Biomedical subjects

R G Bevilacqua

Publications and source records attributed to R G Bevilacqua.

79 records · Page 5Linked to original sources
PubMedDate not supplied

[Levels of hepatic fats in jejuno-ileal bypass. Experimental study].

Liver failure is a serious complication when small bowel bypass is used for control of obesity. To analyse the changes in liver microscopic morphology and liver fatty acids content, 42 rabbits divided in two groups were studied. The 21 animals of group I had 50% of the distal jejuno-ileum excluded and anastomosed to the cecum. The proximal 50% were anastomosed to the distal 5 cm of the ileum. The 21 animals of group II were used as controls and were submitted to a laparotomy and small bowel manipulation. Liver histology and fatty acids content were studied at the time of these operations and in the 21st postoperative day. No signficant histologic changes were noticed in both groups. A significant decrease in liver fatty acids content was observed in groups I and II. However, the decrease in group II was less pronounced than in group I. This last observation appears to support the theory of liver lipid metabolism impairment after small bowel bypass, even in the absence of obesity.

Animals↗
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[Multicentric myxoid, metachronous and synchronous and multifocal liposarcoma: report of a case].

A case of a male patient, 66 years old, who exhibited in a period of six years many multicentric and multifocal synchronic and metachronic myxoid liposarcomas is reported. The authors made a revision of cytogenetics and DNA alterations recently identified in this type of tumor. The chromosomic alterations are represented by the translocation t(12;16) (q13;p11) and trisomy of the chromosome 8. The genic analysis revealed the presence of altered restriction fragments due to highly specific and reproducible methylation differences. In conclusion the authors suggest that the presence of the multiple tumors of this type in the same patient could be due to a common etiologic factor, not yet known, as being the initiator of this systemic illness of the fat tissue.

Abdominal Neoplasms↗
PubMedDate not supplied

[Gastric epithelioid leiomyosarcoma simulating pancreatic pseudocyst. Report of a case and review of the literature].

The authors report a case of malignant gastric leiomyoblastoma (epithelioid leiomyosarcoma) which was mistaken for a pseudocyst of the pancreas. The patient was operated several times in another hospital. At one of the operations a cystogastrostomy was performed. In november, 1989, when operated again by us, a large tumoral mass arising from the posterior gastric wall was found. The histopathological diagnosis was leiomyoblastoma of the stomach. It is concluded that the wall of a pancreatic cystic lesion should always be submitted to histologic examination in order to be excluded the possibility of a malignant neoplasm.

Biopsy↗
PubMedDate not supplied

Gastro-esophageal isoperistaltic bypass in the palliation of irresectable thoracic esophageal cancer.

METHODS: The authors retrospectively review 22 patients with irresectable esophageal cancer in whom an isoperistaltic substernal gastric esophagogastric bypass was performed. RESULTS: After the operation eighteen patients (82%) regained normal swallowing. Seven patients developed anastomotic stenosis that was successfully treated in six by surgery or endoscopic dilatation. Two patients evolved with cervical fistulae until their death. As a whole, there was a statistically significant improvement in swallowing capability (p = 0.0352). Seventeen patients (77%) had postoperative complications, the most common being cervical fistulae (in 13.59%), pneumonia (in 10.45%) and anastomotic stenosis (in 7.32%). Postoperative morbidity was significantly associated with preoperative diseases and ASA class III (p < 0.05). There were three postoperative deaths (14%). Postoperative mortality was significantly related to severe malnutrition and preoperative associated disease (p < 0.05). CONCLUSIONS: The conclusion is that the procedure has acceptable morbidity and mortality for the population under consideration, permitting palliation of dysphagia in the majority of cases.

Adult↗