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Biomedical subjects

R G Blaker

Publications and source records attributed to R G Blaker.

9 recordsLinked to original sources
PubMed1977

Insertional translocation into the X chromosome of a 46,XY male.

A baby boy with multiple congenital anomalies and low birth weight has an apparent de novo insertional translocation into the long arm of his only X chromosome. The origin of the translocated material is not evident and both cytogenetic and X-linked marker studies do not indicate any loss of genetic material from the X chromosome. His findings are compared with other males who have X-translocations, none of which appear to be insertional translocations.

Abnormalities, Multiple↗
PubMed1975

Improved estimation of urinary myoglobulin by counterimmunoelectrophoresis, as compared with the double immunodiffusion technique.

We describe a simple, sensitive, and relatively inexpensive counterimmunoelectrophoretic technique for detection and estimation of myoglobin. The test can be completed within 90 min, compared with 12-48 h required by double immunodiffusion. With the counterimmunoelectrophoretic technique we could detect myoglobin in concentrations of 2-3 mg/liter, while the detection limit by double immunodiffusion was about 9 mg/liter.

Evaluation Studies as Topic↗
PubMedDate not supplied

Correlation of disease activity in systemic necrotizing vasculitis with immune complexes.

Ninety-four sera from 23 patients with necrotizing vasculitis of the polyarteritis nodosa (PAN) type were examined for immune complexes by polyethylene glycol (PEG) precipitation. The presence of immune complexes in serum specimens was positively correlated with the presence of active disease in PAN (p less than .001). These complexes predicted active disease 93% of the time and their absence predicted a period of inactivity 54% of the time. The presence of hepatitis B markers, Clq immune complexes, rheumatoid factor, or low complement levels did not correlate with active disease. In 9 patients in whom serial specimens were tested for immune complexes there was a positive association of immune complexes and active PAN.

Adult↗