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Biomedical subjects

R G Christiansen

Publications and source records attributed to R G Christiansen.

17 recordsLinked to original sources
PubMed1996

Successful treatment of phenol poisoning with charcoal hemoperfusion.

A 50-y-old Caucasian female inadvertantly received 30 ml of 89% phenol (26.9 g, 0.44 g/kg bw) [corrected]. At 23 min post-injection the patient was unresponsive and in shock. By 4 h post-injection she required large doses of vasopressors. At 4.5 h, charcoal hemoperfusion (CHP) was begun and she received that for 6 h and 20 min. Her clinical status improved during the CHP and she made a complete recovery. Phenol levels drawn prior to and after the procedure correlated her recovery with the improving phenol levels. CHP appears to have efficacy in severe acute phenol intoxication.

Blood Proteins↗
PubMed1994

Androgen receptor affinity of 5'-acyl furanosteroids.

Syntheses of 5'-acyl furanosteroids are described from the corresponding unsubstituted [3,2-b]furanosteroids using acid anhydrides and acid chlorides in the presence or absence of Lewis acids. New methods have been developed to prepare 5'-acetyl derivatives: reduction of a 5'-trichloroacetyl intermediate either by sodium formaldehyde sulfoxylate or with 10% Pd/C. Most of these 5'-acyl derivatives bind to the rat ventral prostate androgen receptor. However the antiandrogenic activity was diminished when compared with 4,5'-methylsulfonyl furanosteroid. Biological studies revealed that 5'-acyl furanosteroids were either androgens or modest antiandrogens. The electrostatic potential maps of the substructures of 3, 4, and 5'-acetyl syn- and anti-furanosteroids showed striking differences which may explain, to some extent, the lack of significant antiandrogenic activity of 5'-acyl furanosteroids.

Androgen Antagonists↗
PubMed1992

Attitudes of part-time community internal medicine faculty about their teaching.

The authors sent a six-item questionnaire regarding attitudes about teaching to 130 part-time community internal medicine faculty at the University of Illinois College of Medicine at Rockford in August 1991; of the 90 (69%) who responded, 53 were salaried and 37 nonsalaried. Substantial numbers of the salaried faculty responded (1) that teaching is important for their career development (25, 48%), compared with nine (22%) of the nonsalaried faculty, and (2) that they expected to increase their commitments to the medical school (50, 75%), compared with 24 (65%) of the nonsalaried faculty. Of all the faculty, fewer than the authors expected--22 (24%)--felt that their teaching interfered with their clinical practices. As expected, most (76, 84%) responded that salary was necessary. The authors suggest that their results may be helpful to other medical schools, because with the setting of medical education changing from the hospital to the community, the importance of part-time faculty is increasing.

Attitude↗
PubMed1992

A multidisciplinary approach to information management and critical appraisal instruction: a controlled study.

A study of the effectiveness of a collaborative course in teaching library and critical appraisal skills was conducted at the University of Illinois College of Medicine. A critical appraisal and library skills course was taught at the Peoria site during the third-year medical clerkship. The performance of Peoria students on a twenty-item multiple choice posttest was compared to that of third-year students in Rockford, who received no library or critical appraisal instruction during their medicine clerkship. The two groups were similar in self-perceived library skills, critical appraisal skills, and other demographic values. Peoria students scored significantly higher on library, critical appraisal, and total posttest questions. An improving trend during the year was not observed at either site, implying that students were not acquiring these skills in day-to-day clerkship activities. Results suggest that this multidisciplinary course is effective in teaching library and critical appraisal skills.

Curriculum↗
PubMed1991

Primary care teaching physicians' losses of productivity and revenue at three ambulatory-care centers.

This study reports two years of basic data concerning University of Illinois clerkship students, their teaching faculty, and their patients at three community health centers. Students from four classes (1985, 1986, 1987, and 1988) were studied in 1985 and 1986. The faculty were family physicians, internists, and pediatricians who provided 20% of the undergraduate medical education for the last 30 months of a four-year curriculum. The study's goal was to develop estimates of the primary care teaching physicians' productivity, to compare them with the productivity of physicians not involved in teaching, and to provide estimates of revenue shortfalls that occurred for the physicians who were teaching. The estimated productivity of the teaching physicians, working 29 hours a week in ambulatory-care settings, was lower by 30-40% when they were teaching medical students than the productivity of nonteaching physicians regionally and nationally. The average patient-care revenue loss for a full-time-equivalent faculty member per full-time-equivalent student for 1985 was estimated to be $27,531 (regional comparison) or $21,143 (national comparison). The corresponding figures for 1986 were $24,294 and $21,525, respectively. The study's results should be useful to those who are planning to establish ambulatory-care delivery systems and also to directors of existing ambulatory-care delivery systems who may be contemplating accepting medical students.

Community Health Centers↗
PubMed1990

Antiandrogenic steroidal sulfonylpyrazoles.

The steroidal sulfonylpyrazole 1 bound to the rat ventral prostate androgen receptor in vitro; it inhibited testosterone propionate induced increases in ventral prostate weight in vivo in the castrated, immature male rat with an ED50 of 15 mg/kg po. Compound 1 lacked androgenic activity in vivo in contrast to the parent steroidal pyrazole 5, which was both androgenic and antiandrogenic. The 2'- and 5'-methylsulfonyl isomers 6 and 6a did not bind to the androgen receptor. Introduction of an alkylsulfonyl at the N-1'-position has served, therefore, to isolate the intrinsic antiandrogenic properties of the steroidal heterocycle free of apparent hormone agonist properties. Structure-activity relationship studies revealed that a methylsulfonyl group at N-1' together with a C-17 alpha-substituent were the optimal combination for in vitro androgen receptor binding, in vivo antiandrogenic potency, and a lack of androgenic activity.

Androgen Antagonists↗
PubMed1986

A proposal for a combined family practice--internal medicine residency.

Both family practice and internal medicine currently train graduates for primary care. A single, four-year program is proposed that combines the strengths of family practice and internal medicine, incorporates community needs into the curriculum, and addresses the physician's changed role in a revolutionized health care provision system. Specific training recommendations and the societal and professional advantages of such a program are detailed.

Delivery of Health Care↗
PubMed1982

The acute vasculitis of Wegener's granulomatosis in renal biopsies.

The kidney biopsy specimens from five patients with Wegener's Granulomatosis were reviewed in an attempt to characterize the early histological lesion when vasculitis was present. The vascular lesions were found mainly in interlobular-sized arteries. The acute vascular lesions were sparse and focal, mainly localized to the intimal area, and with fibrinoid material and platelets constituting the early infiltrate. The electron microscopy and scanning electron microscopy of the involved areas further emphasized the presence of platelets in the early lesion, and accentuated endothelial alterations occurring along with the intimal infiltrate. Morphologic evidence of immune complex presence was not found.

Adult↗
PubMed1977

Isolation, synthesis, and biological activity of five metabolites of danazol.

Metabolites of danazol (17 alpha-pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol), an orally effective pituitary gonadotropin inhibitory agent devoid of estrogenic and progestational activites, were isolated from urine of a female subject who had taken danzol orally at a dose of 800 mg/day for 7 days, The metabolites isolated were 17-hydroxy-17alpha-pregn-4-en-20-yn-3-one (11), 17-hydroxy-2alpha-(hydroxymethyl)-17alpha-pregn-4-3n-20-yn-3-one (5), 17-hydroxy-2-(hydroxymethyl)-17alpha-pregna-1,4-dien-20-yn-3-one(7), 6beta,17-dihydroxy-2alpha-(hydroxymethyl)-17alphapregn-4-en-20-yn-3-one(8), and 6beta, 17-dihydroxy-2(hydroxymethyl)-17alphapregna-1,4-dien-20yn-3-one(10). None of these metabolites exhibited pituitary inhibiting activity comparable to danazol.

Animals↗
PubMed1965

A study of phagocytosis in the ameba Chaos chaos.

The process of phagocytosis was investigated by observing the interactions between the ameba Chaos chaos and its prey (Paramecium aurelia), by studying food cup formation in the living cell, and by studying the fine structure of the newly formed cup using electron microscopy of serial sections. The cytoplasm surrounding the food cup was found to contain structures not seen elsewhere in the ameba. The results are discussed in relation to the mechanisms which operate during food cup formation.

Eukaryota↗