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Biomedical subjects

R G Closson

Publications and source records attributed to R G Closson.

12 recordsLinked to original sources
PubMed1990

An intravenous potassium policy with concurrent physician evaluation.

Hospitals have an ethical, as well as a legal, duty to provide safe care to patients. Responsibility for providing care involving medications is distributed to practitioners within the institution including physicians, nurses, and pharmacists. Each practitioner plays an essential role in the provision of safe intravenous potassium supplementation. A procedure is described which incorporates drug usage evaluation into a safe, simple, intravenous potassium policy.

California↗
PubMed1990

Multi-institutional drug-use evaluation of intraocular irrigating solutions.

A collaborative drug-use evaluation (DUE) of intraocular irrigating solutions (IOISs) at ophthalmic specialty hospitals nationwide is reported. Qualifying criteria for the use of an expensive fortified IOIS product were (1) the duration of surgery is more than 60 minutes, (2) the surgery is performed without a viscoelastic agent, (3) the patient's age is less than 50 years, (4) the patient has diabetes, and (5) the patient has evidence of compromised corneal endothelium. Surgical cases involving the use of IOISs were identified at each institution, and those cases involving fortified IOIS were reviewed for conformance with the criteria established. Of 23 institutions, 10 were able to perform the DUE. The review was concurrent at one institution and retrospective at the other nine. A case had to meet only one criterion to be considered in conformance. The cumulative mean rate of conformance with at least one criterion was 74%; the median conformance rate was 91%. The criteria that most frequently justified the use of fortified IOIS were surgical duration and nonuse of a viscoelastic material. Conformance with the DUE criteria varied with the institution, but valuable knowledge about the use of intraocular irrigating solutions was obtained by all.

Adult↗
PubMed1984

Drug-induced seizures: a 10-year experience.

Of 53 patients with drug-induced seizures seen in the last decade, 45% had single seizures, 40% had multiple convulsions, and 15% had status epilepticus. Generalized seizures with focal features were common, but simple partial (motor) seizures occurred in only two patients. Isoniazid, insulin, lidocaine, and psychotropic medications were the most common drugs that caused seizures. Forty-nine patients recovered without ill effects, but 4 patients died of cardiovascular complications. The combined cardiovascular toxicity of the convulsants, antidotes, and anticonvulsants was more important than the number or duration of seizures in determining outcome.

Adolescent↗
PubMed1979

Research in clinical pharmacy: needs and priorities.

The importance of research to a service profession such as pharmacy is established. The current state of research in clinical pharmacy, and some proposed priorities for the future, are outlined. General requirements for research staff, facilities, and funding are listed. To produce accurate and meaningful results, three guidelines must be borne in the minds of researchers: (1) select research topics that will have recognized impact on the quality of patient care and education; (2) design and conduct studies which can withstand the scrutiny of the established scientific community; and (3) communicate meaningful information to all who can facilitate its utilization.

Health Services Research↗
PubMed1977

Terminal half-lives of drugs studied in patients with hepatic diseases.

Published evidence of the effects of liver diseases on the terminal half-lives of drugs in man is presented. Formulas are given to aid the reader in determining the hepatic clearance of drugs. The effect of various liver diseases on hepatic function is reviewed. Data on 38 drugs are tabulated.

Half-Life↗