Circulating adrenocorticotropin (ACTH) as a controlled variable in the regulation of ACTH secretion.
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Biomedical subjects
Publications and source records attributed to R G Conrad.
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Incubation of rat adenohypophyses in a high concentration of potassium increases adrenocorticotropic hormone release. This increased release is suppressed by the addition of corticosterone to the incubating medium. Our findings are consistent with a process of "stimulus-secretion coupling" proposed for other glands and suggest that corticosterone may operate directly on the adenohypophysial cell membrane to inhibit releasing mechanisms.
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