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Biomedical subjects

R G Font

Publications and source records attributed to R G Font.

At least 19 recordsLinked to original sources
PubMed1986

A multicenter study of ranitidine treatment of duodenal ulcers in the United States.

Treatment of duodenal ulcer with the histamine H2-receptor antagonist, ranitidine, was assessed in a double-blind, randomized, multicenter trial in which patients were treated for two consecutive 4-week periods with ranitidine 150 mg b.i.d. or a placebo. All patients were allowed to take antacids as necessary for symptoms. Three hundred eighty-two patients were entered and 355 completed the first 4-week trial period. Ranitidine significantly improved healing at 2 weeks (37 versus 19%, p less than 0.01) and at 4 weeks (73 versus 45%, p less than 0.01), with better relief of pain and lower use of antacids. In the second 4-week trial period, 124 unhealed patients from the first 4 weeks were re-randomized. Ranitidine treatment resulted in a greater healing rate regardless of previous treatment (p less than 0.05). In this trial, side effects were uncommon and not different between placebo and the tested drug. One case of hepatitis in the ranitidine treated group was presumed on the evidence to be non-A non-B. Ranitidine is effective and appears to be safe in the treatment of duodenal ulcer and its symptoms.

Adult↗
PubMed1981

Double-blind multicenter comparison of 1,200 mg. and 1,000 mg. cimetidine in hospitalized and ambulatory duodenal ulcer patients.

A multicenter double-blind study was made to compare whether 1,000 mg dosage of cimetidine, the dose commonly employed in the United Kingdom, was as effective as the 1,200 mg. dose recommended in the United States for the treatment of duodenal ulcer. Our second goal was to test whether hospitalization would enhance the efficacy of cimetidine in the healing of duodenal ulcer. There was no difference in healing rate after either one (40%) or four (86%) weeks of therapy. In addition, hospitalization (one week) did not enhance the efficacy of cimetidine therapy.

Adult↗
PubMed1978

Gastritis polyposa in a gastroenterostomy anastomosis.

Review of the literature finds a strong point made for polyps of the stomach to be considered as "sentinels" of malignancy. The controversy over the transformation of gastric polyps into malignant tumors is coming to an end. Apparently, everyone agrees with a high incidence of malignant transformation in adenomatous polyps. The recent case report by Papp and Joseph of a hyperplastic polyp with malignant changes, seems to demonstrate that all polyps can undergo neoplastic transformation. We believe that every gastrectomized patient should be gastroscoped once a year, even with an absence of symptoms or lack of x-ray findings. Any polyp, adenomatous or hyperplastic, should be removed endoscopically and studied histopathologically for possible association with or development of carcinoma.

Adult↗
PubMed1975

[Raised trypsin concentration in duodenal secretion after a test meal (Lundh test) (author's transl)].

The Lundh test for exocrine pancreatic function was performed on 376 patients. An increased trypsin concentration in duodenal secretion (greater than 28.9 IU/ml) was measured in eight. Seven of them had symptoms of pancreatic disease, six of them with acute episodes. Eight further cases have been reported in the literature, at least two of them definitely having pancreatic disease. Both in the reported cases and in the authors' study the proportion of patients with abnormally raised enzyme concentrations among the group of patients with acute or subacute pancreatitis was significantly greater than in a control group. It is possible that abnormally raised enzyme concentration is due to subacute pancreatic disease and may at times be the only finding. An abnormally raised enzyme concentration in the Lundh test should therefore simply be classified as such and not be taken as the expression of normal or even "excellent" pancreatic function.

Acute Disease↗
PubMed1975

Comparative study of secretin and Lundh tests.

Exocrine pancreatic function in 19 patients with pancreatic disease and in 14 of 16 controls was measured by secretin stimulation and by the Lundh test on two different occasions. Peak bicarbonate concentration in the Lundh test emerged as the most reliable parameters. No additional diagnostic value was obtained by measuring enzymes after secretin injection. In 6 patients with chronic and in 8 of 13 patients with acute pancreatitis, both tests gave results that agreed with each other. The remaining 5 patients showed either an abnormal secretin value or an abnormal Lundh test. This is consistent with the wide variation seen in acute pancreatitis. It is concluded that the Lundh test as well as the secretin test were of value in the assessment of chronic pancreatic disease. The secretin test may be slightly more sensitive to mild and acute pancreatic damage than is the Lundh test. However stimulation of the pancreas by a test meal is easier to perform and more economic.

Acute Disease↗