PubMed Health⌕ Search

Biomedical subjects

R G Gulevich

Publications and source records attributed to R G Gulevich.

11 recordsLinked to original sources
PubMed2006

[The effect of methyl-containing supplements during pregnancy on the phenotypic modification of offspring hair color in rats].

The effect of methyl supplements to the diet of pregnant homozygous (AAHH) female rats with agouti coat color mated with homozygous (aahh) males on the phenotypic modification of the coat color of their heterozygous offspring (AaHh) has been studied. Comparative morphological analysis of the main parameters of hair that determine coat color, including the total length of hairs of different types and the length of the upper black (eumelanin) and light (pheomelanin) parts of awn hairs has been performed. The pattern of pigment granule distribution among hair layers has been analyzed. The melanin content of the hair has been determined using electron spin resonance (ESR). Although all offspring have a typical agouti coat color (alternating black and light portions of hair), 39% of them have a darker coat color than control and other experimental rats have. The main differences between the offspring with darkened and standard coat colors are accounted for by the ratio between the eumelanin and pheomelanin portions of awn hairs. In darkened offspring, this ratio is significantly higher than in control rats. The possible mechanisms of the phenotypic modification of agouti coat color in experimental animals are discussed.

Agouti Signaling Protein↗
PubMed2004

Effect of selection for behavior on pituitary-adrenal axis and proopiomelanocortin gene expression in silver foxes (Vulpes vulpes).

Silver foxes from a commercial population (farm bred or unselected for behavior control) and from populations selected for tame behavior and enhanced aggressiveness towards man have been investigated. Plasma cortisol and adrenocorticotropic hormone (ACTH) levels, pituitary ACTH levels, POMC gene expression in the anterior pituitary, and corticotropin-releasing factor (CRF) gene expression in the hypothalamus were assessed. The results indicate that the males from the tame-behavior group have lower plasma cortisol and ACTH levels and POMC gene expression in the anterior pituitary in response to capture and handling in comparison with unselected ones. Foxes from the aggressive behavior group also have lower POMC expression, although plasma cortisol and ACTH levels remain the same as in unselected ones. The three groups of animals show no significant changes in the ACTH level in the pituitary and CRF expression in the hypothalamus.

Adrenocorticotropic Hormone↗
PubMed2003

Relationship between behavioral selection and primary and secondary immune response in wild gray rats.

The main characteristics of primary and secondary immune response (number of antibody producing cells and the amount of produced antibodies) are reduced in rats selected by elimination of aggressive behavior in comparison with animals selected by stimulation of this behavior. In parallel, the reaction of the pituitary-adrenal system during immune response was modified in these rats. Presumably, the differences in immune reactions of rats selected by contrast behavior are determined by changes in reactivity of the pituitary-adrenal system to stress and immune stimulation during selection.

Aggression↗
PubMed2003

[Effect of repeated stress on the function of pituitary-adrenal and immune systems in gray rats selected for behavior].

Reaction of pituitary-adrenal axis to a 10-day immobilisation stress and a humoral immune response to subsequent injection of sheep red blood cells were investigated in gray rats selected for enhancement of decrease of aggressive behavior towards humans. It was show that pituitary-adrenal axis reaction of aggressive animals to repeated stress did not change during the experiment, while a decrease of stress-induced corticosterone level was observed already on day 5 of stress. Repeated stress led to enhancement of humoral immune response in aggressive rats, whereas it did not bring about any change in tame animals. based on the obtained data, it could be supposed that breeding of gray rats for domesticated behavior led a faster adaptation to repeated stress and the absence of stimulating influence on humoral immune response in tame rats.

Aggression↗
PubMed1995

Gonadal function in mink under artificial photoperiods.

Exposure of juvenile minks to artificial light conditions imitating early autumn (additional illumination from 20 June to 20 July followed by 8 h daylight from 21 July to 10 October--photoperiod I; 8 h daylight from 21 July to 10 October--photoperiod II) induced the prolonged modification of sex steroid concentrations. The increase in plasma testosterone concentrations during the prepubertal period was followed by a decrease before and during the mating period in experimental males. The concentration of oestradiol in plasma increased just before the start of the mating period (January and February) in females under photoperiod I, and these hormonal changes were accompanied by an increase in fertility. The conditions of photoperiod II (involving fewer hours of daylight) had less effect on the sex steroid concentration in the blood of females, and fertility was not changed. The response of gonads to hCG injection at the beginning of puberty (November) was higher in males exposed to photoperiod I conditions and in females exposed to both photoperiods than in control animals.

Animals↗
PubMedDate not supplied

[Gonadal and adrenal endocrine functions in female minks of 2 genotypes in postnatal ontogeny].

Radioimmune assay has been made of the content of estradiol and progesterone in the blood (from July to March including the 7th day after mating), as well as on the level of estradiol and progesterone production in young females of the standard and mutant sapphire minks in November. It was shown that within certain periods, estradiol and progesterone content of the blood was significantly higher in the standard animals. Gonadal production of estradiol, as well as progesterone production both by the gonads and adrenals in November, were similar in females of both genotypes. It is suggested that sapphire minks have another pattern of correlation between estradiol content of the blood and gonadal production of estradiol as compared to that in standard animals.

Adrenal Glands↗
PubMedDate not supplied

[The potential fertility, embryonic development and hormonal status of rats selected for their estrous cycle reaction to constant illumination].

Illumination responsiveness (IR) is studied by selection experiments with outbred Wistar rats. Under selection is estrous cycles under permanent illumination (PI) condition, changes in hormonal status, potential fertility, and embryonic developments ats different stages are registered and compared with control. Results indicate significant changes in endocrine regulatory system in the lines exposed to PI. Functional potentiality of reproductive system gets more weak as a result of this selection, which leads to decreasing in number of ovulations, defective development of placenta, less embryo weights, higher embryo mortality. The opposite conditions are observed in rats undergone selection of stability of estrous cycle. It is concluded that the above selection reveals formation of regulatory mechanisms of reproduction on different genetical physiological bases.

Animals↗
PubMedDate not supplied

[Adrenal function in the mink Mustela vison selected for the type of behavior].

Glucocorticoid function of adrenals and its reactivity to stress caused by immobilization and to ACTH stimulation have been studied in the male minks selected both for domestic and aggressive behavior towards man. In autumn period the regression of cortisol content in adrenals was observed in domesticated males and particularly in aggressive ones compared with control. At the same period the increased level of cortisol in blood as the result of immobilization was noticed in aggressive minks compared with the domesticated and control ones. At ACTH stimulation in spring time the increase of cortisol level in blood was shown for animals of all the groups but it was more marked for the aggressive ones.

Adrenal Glands↗