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Biomedical subjects

R G Haddad

Publications and source records attributed to R G Haddad.

10 recordsLinked to original sources
PubMed1995

Bone mineral density and the risk of fracture in patients receiving long-term inhaled steroid therapy for asthma.

To determine whether high-dose or prolonged inhaled steroid therapy for asthma increases a patient's risk of osteoporosis and fracture, we measured bone density in 26 men and 43 women (41 postmenopausal, all of whom had received supplemental estrogen therapy) after treatment with an inhaled steroid for 10.1 +/- 5.5 years and oral prednisone for 10.7 +/- 9.7 years (mean +/- SD). Most had stopped receiving prednisone since commencing the inhaled steroid therapy. We found that bone densities (adjusted for age and sex to yield a z score) were lower in association with higher daily doses of inhaled steroid (p = 0.013 ANCOVA) and with the duration of past prednisone therapy (p = 0.032). Larger cumulative inhaled steroid doses were associated with higher bone densities (p = 0.002) and a reduction in the numbers of patients at risk of fracture. Bone density also increased with the amount of supplemental estrogen therapy (p = 0.058) and, at equivalent levels of inhaled and oral steroid use, women showed higher bone density z scores than did men. Women with a lifetime dose of inhaled steroid greater than 3 gm had normal bone density regardless of the amount of past or current prednisone use or the current dose of inhaled steroid. These data indicate that the daily dose, but not the duration, of inhaled steroid therapy may adversely affect bone density, and that estrogen therapy may offset this bone-depleting effect in postmenopausal women.

Administration, Inhalation↗
PubMed1993

An anatomic, radiographic, and biomechanical assessment of extrapedicular screw fixation in the thoracic spine.

This study performed a thorough review of the pertinent thoracic spine anatomy to determine the appropriate landmarks for extrapedicular screw placement and indentified the anatomic structures at risk; assessed the safety and accuracy of the newly proposed screw insertion technique; determined the stability and strength of this new screw position through biomechanical testing; and analyzed the stability of this extrapedicular screw location with respect to bone mineral density of the vertebra.

Biomechanical Phenomena↗
PubMed1989

Radiologic investigation of low back pain.

Low back pain is one of the commonest disorders, yet is the most confusing. The cost in work-time lost and in the search for and treatment of its many causes amounts to billions of dollars annually. The traditional techniques for anatomic visualization have been plain-film radiography and myelography, but they have limitations. The development of computed tomography and magnetic resonance imaging have substantially improved anatomic imaging. However, invasive procedures, such as discography, percutaneous nerve-root blocking and percutaneous facet injection, may be helpful in patients with disabling pain in whom noninvasive methods give negative findings, show abnormalities that do not correlate with the symptoms or identify multiple sites of disease. The invasive procedures are believed by some to be associated with too many complications. We have attempted to clarify the strengths and weaknesses of the currently available methods of investigating low back pain and the indications for their use.

Adult↗
PubMed1988

Longitudinal stress fracture of the tibia: case report.

Stress fractures usually present with vague clinical features and delayed radiographic findings. A patient with a longitudinal stress fracture of the tibia is described here. Computed tomographic images, perpendicular to the fracture, were diagnostic while plain radiographs and scintigraphy showed nondiagnostic changes due to an unexpected fracture pattern.

Cumulative Trauma Disorders↗
PubMed1986

Radiocarpal arthroscopy and arthrography in the diagnosis of ulnar wrist pain.

The purpose of this prospective study was to compare arthroscopy with arthrography in the diagnosis of ulnar wrist pain. Thirty-seven consecutive patients with ulnar wrist pain but normal routine and stress radiographs had dynamic and static radiocarpal arthrograms (R.G.H.) and arthroscopy (J.H.R.) performed. Sixteen arthrograms demonstrated a leak of contrast into the distal radioulnar joint. Arthroscopy demonstrated a perforation of the triangular fibrocartilage complex in all 16. Seven arthrograms demonstrated a leak of contrast into the midcarpal joint. Arthroscopy demonstrated lunotriquetral instability in two and no abnormality in five. Seventeen arthrograms showed no abnormality. Arthroscopy confirmed no abnormality in nine but also demonstrated seven triangular fibrocartilage perforations and one case of isolated lunate chondromalacia. Arthroscopy findings were confirmed in eight patients who underwent a subsequent arthrotomy. Radiocarpal arthroscopy is superior to arthrography in the diagnosis of chronic ulnar wrist pain.

Adolescent↗
PubMed1984

Budd-Chiari syndrome with inferior vena cava obstruction associated with systemic lupus erythematosus.

The Budd-Chiari syndrome is an uncommon condition in which hepatic venous outflow is obstructed by thrombosis of the major hepatic veins. Many of the cases are idiopathic, but it has been described in association with vena caval webs, abdominal trauma, retroperitoneal neoplasms, and hypercoagulable states. A patient with systemic lupus erythematosus (SLE) who developed the Budd-Chiari syndrome with inferior vena cava thrombosis led to a review of the possible association between SLE and the Budd-Chiari syndrome. The therapy of the Budd-Chiari syndrome with associated vena cava thrombosis is also discussed.

Adult↗