PubMed Health⌕ Search

Biomedical subjects

R G Hendrickse

Publications and source records attributed to R G Hendrickse.

At least 91 records · Page 5Linked to original sources
PubMed1968

Measles vaccination with reduced dosage.

A field trial is reported in which good sero-conversion rates were obtained when a dose of 200 TCID(50) Beckenham 31 strain (Wellcovax) measles vaccine was administered by Ped-O-Jet subcutaneously in a volume of 0.5 ml. per dose. It is suggested that use of this reduced dosage would lead to a significant reduction in the cost per dose of the vaccine, especially when administered on a scale large enough to justify the use of multidose containers.

Child, Preschool↗
PubMed1965

A further study on measles vaccination in Nigerian children.

Measles is a serious disease in Nigeria, causing severe morbidity and appreciable mortality; it occurs almost exclusively in the pre-school child with a peak incidence in the second year of life. A safe measles vaccine would be of inestimable value both in that country and in other areas where the disease constitutes a grave menace. Studies using vaccines of the Enders Edmonston B type have shown that while these are efficient immunizing agents, severe reactions are too frequent to permit of their wide general use. In the quest for safer vaccines, and in accordance with the recommendations of a WHO Scientific Group, a field trial was undertaken in Western Nigeria in May 1964 to make direct comparisons of the antigenicity and reaction rates of three further-attenuated measles vaccines (Schwarz, Beckenham 20 and Beckenham 20/2) and Enders Edmonston B vaccine plus gamma-globulin. A control group was also included.Analysis of the clinical responses demonstrated that reactions were similar, and of minimal severity, in all vaccine groups. Neutralizing antibody responses showed that all the vaccines used were effective immunizing agents. From the point of view of ease of administration and expense, however, further-attenuated vaccines seem preferable to Enders Edmonston B administered with gamma-globulin.

Female↗