Biomedical subjects

R G Kettrick

Publications and source records attributed to R G Kettrick.

23 records · Page 2Linked to original sources

PubMed1982

Improvement in lung mechanics as a function of age in the infant with severe bronchopulmonary dysplasia.

Pulmonary function tests were performed in two groups of infants with bronchopulmonary dysplasia; a group less than 7 months of age with severe ventilator-dependent respiratory failure (Group A), and a group 7-22 months of age during resolution of their disease (Group B). Group A patients had significantly elevated minute volume, low specific compliance, elevated inspiratory and expiratory pulmonary resistance, and low functional residual capacity. Group B patients also demonstrated elevated minute volume, whereas specific compliance, inspiratory pulmonary resistance and functional residual capacity were within normal limits, and expiratory pulmonary resistance was only slightly above normal. With the exception of minute volume, the differences between the groups were significant (P less than 0.05). Sequential studies of resistance and compliance over 4-5 months in two patients in the younger group demonstrated values that approached or achieved normal range. It is concluded that pulmonary mechanics improve with age in the infant with severe bronchopulmonary dysplasia.

Aging↗

PubMed1982

Management of the drowning victim.

Our ability to manage the near-drowning victim at the site of the accident and in the advanced life support facility has allowed for an increased survival and a decrease in morbidity. Nevertheless, the greatest strides in the management of drowning must of necessity be in the area of preventive medicine. A greater appreciation of the epidemiology of immersion accidents will allow the development of education and surveillance programs to minimize the frequency of these devastating accidents.

Adolescent↗

PubMed1981

Clinical correlates of successful weaning from mechanical ventilation in severe bronchopulmonary dysplasia.

The hospital records of 7 patients with severe bronchopulmonary dysplasia (BPD) were reviewed. All patients were ventilator dependent for prolonged periods (mean duration intermittent mandatory ventilation (IMV) 14.3 +/- 3.5 months) but eventually were successfully weaned from mechanical ventilation and sent home. The early phase of the disease was characterized by excessive CO2 retention, tachypnea, and inability to tolerate reductions in IMV. A turning point was reached halfway through the course of mechanical ventilation (7.3 +/- 1.4 months) which was identified by a persistent and significant reduction in PaCO2 and spontaneous respiratory rate. Thereafter, gradual reductions in IMV were generally well tolerated. Average monthly weight gain was less prior to the turning point it was subsequently.

Bronchopulmonary Dysplasia↗

PubMed1980

Agenesis of the left diaphragm: surgical repair and physiologic consequences.

Agenesis of the hemidiaphragm is an unusual congenital anomaly associated with a high mortality. This paper presents the fourth patient to survive the neonatal period with agenesis of the hemidiaphragm. He was an identical twin, weighing 1.5 kg and his clinical course was characterized by ipsilateral pulmonary hypoplasia, large alveolar-arterial gradient for oxygen, persistent fetal circulatory pattern and ventilator dependence. These abnormalities suggest a pathophysiology similar to that observed in patients with Bochdalek hernia. The surgical correction, postoperative care and observation of pulmonary function following repair of agenesis of the left diaphragm are described.

Diaphragm↗

PubMed1980

Pulmonary function in chronic respiratory failure of infancy.

We studied pulmonary function in 7 infants age 3-16 months who were dependent upon mechanical ventilation due to bronchopulmonary dysplasia (BPD). Raised lower expiratory airway resistance (RAe), low dynamic lung compliance (CL) and rapid respiratory frequency (f) characterized the breathing pattern in these infants. End-tidal carbon dioxide tension (PECO2) was elevated in spite of abnormally high minute ventilation (VE). One infant died of respiratory failure, 1 died of sepsis and 1 of an occluded tracheostomy after discharge from the hospital. Another infant still requires mechanical ventilation at age 18 months. Recovery from chronic respiratory failure in 4 infants occurred between age 1.2-2.5 years. The infants recovered concomitant with the ability to sustain a high VE in spite of persistently elevated RA and low CL. All of the surviving infants, although developmentally delayed, have the potential for home care with further growth and development.

Airway Resistance↗