The inhalation toxicity of sulfolane (tetrahydrothiophene-1,1-dioxide).
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Biomedical subjects
Publications and source records attributed to R G Mehl.
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In rodents oral or parenteral administration of sulfolane (tetrahydrothiophene-1,1-dioxide) produced hyperactivity, followed by clonic-tonic convulsions. The analeptic effects of sulfolane were nearly additive with those of Metrazol. When injected simultaneously with pentobarbital, sulfolane decreased pentobarbital sleeping time in mice. But sulfolane increased sleeping time when the barbiturate was administered 1 hr after sulfolane.
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