Mapping out skin cancer: Mohs micrographic surgery.
Explore the source record for details and available documents.
Biomedical subjects
Publications and source records attributed to R G Mora.
Explore the source record for details and available documents.
Non-melanoma skin cancer in its most prevalent types, basal and squamous cell carcinoma, has a variety of clinicopathologic presentations. Recognition of these types will enable the physician to select the most appropriate method of therapy, diminishing the chance of recurrence and the potential for severe physical and psychologic impairment, and even death.
Histologically diagnosed squamous cell carcinoma of the penis in black patients was reviewed through the Tumor Registry of Charity Hospital covering the years 1948 to 1985. There were 175 cases, including 15 cases of squamous cell carcinoma in situ. The overall mortality was 15.4%. Associated second primary malignancies, almost all of which were found after the diagnosis of squamous cell carcinoma of the penis, occurred in 17.7% of the patients.
Kaposi's sarcoma is a multicentric, malignant, neoplastic process that manifests itself as multiple vascular tumors. We present a comparative, retrospective analysis of demographic and survival data involving patients with Kaposi's sarcoma seen at Charity Hospital, New Orleans, over a 35-year period. The proportion of blacks and women is significantly higher than previously reported. Both blacks and men suffered relatively greater morbidity. In addition, the incidence of second primary malignancies in this group of patients is lower than previously reported.
Until recently, cancer of the skin in blacks has been thought to be quite rare. This paper reviews some of the recent findings from several large series of black patients with skin cancer at our institution. Surgical management of representative cases is illustrated.
An exceptionally rare example of nevoid basal cell carcinoma syndrome occurring unilaterally is presented, along with a review of the syndrome. We ruled out the possible association of this case with the linear unilateral basal cell nevus with comedones because of several incongruities, including the absence of epidermal cysts and strialike atrophy and the presence of pigmented basal cell carcinomas. Linear unilateral basal cell nevus with comedones is not a variant of the nevoid basal cell carcinoma syndrome and the tumors follow a benign course. The aggressive, destructive behavior of numerous pigmented basal cell carcinomas that involve the eyelid and medial canthus of the eye and the head and neck area represents important evidence that our patient's condition was not an example of linear unilateral basal cell nevus with comedones.
The incidence of metastasizing cutaneous squamous cell carcinoma is highly variable depending on the series analyzed. A man with an aggressive squamous cell carcinoma had subsequent metastasis to a lymphomatous lymph node, an apparently unique event.
In a series of nineteen black patients with Bowen's disease of the skin diagnosed between 1948 and 1982, twenty-one lesions occurred. Involvement on non-sun-exposed areas was three times more common than on sun-exposed areas. The most common location was the lower extremity. A history of arsenic ingestion could not be confirmed in any of the patients, but was suggested by histopathologic findings in at least one instance. Invasive lesions developed in five patients, three of whom subsequently died from metastatic disease. Five patients also had a second noncutaneous malignancy.
Kaposi's sarcoma in American blacks is relatively rare, according to the literature. Using information from the Tumor Registry of Charity Hospital of Louisiana in New Orleans, we discuss the available data on nineteen black patients (10 men, 9 women), with histologically diagnosed Kaposi's sarcoma between the years 1948 to 1983. The overall mortality rate directly attributable to their disease was 21%. The mean survival of patients dying from disease was 2.0 years from the time of diagnosis. The mean survival for the entire series was 6.1 years. No second primary lymphoreticular neoplasms were reported.
Bifonazole 1% cream (Mycospor 1) was compared to its cream vehicle in the treatment of tinea versicolor, using a once-a-day application for 2 weeks. Patients were evaluated both clinically and mycologically in order to assess the efficacy and tolerance of the medication. 29 patients were evaluated by statistical analysis. Bifonazole cream 1% was shown to be significantly more effective in the treatment of tinea versicolor when used nightly for 2 weeks than was the vehicle cream.
During the last 5 years we examined four black male patients who had features of both lichen planus (LP) and bullous pemphigoid (BP). The clinical disorder included classical lesions of LP along with bullae that developed subsequently and arose on both lesional and nonlesional skin. Histologic findings correlated well with the type of lesion on which biopsy was done, as did the immunofluorescent findings. All patients had features of both LP and BP by direct immunofluorescence and of BP by indirect immunofluorescence of serum and blister fluid.
In two cases of epithelioma cuniculatum, a rather rare form of verrucous carcinoma of the plantar surface of the foot, the lesions were excised by means of microscopically controlled surgery (Mohs' chemosurgery) with successful results, both clinically and cosmetically. Although the tumor is generally slow-growing and often mistaken for a plantar wart, it can cause extensive local destruction. Metastasis has been reported and may be related to anaplastic transformation caused by radiotherapy. In certain cases, amputation may possibly be avoided through the use of microscopically controlled surgery.
Cancer of the lip in blacks is rare, according to the literature. Using information obtained from the Tumor Registry of Charity Hospital of Louisiana in New Orleans, we discuss data on thirty-six black patients having a total of thirty-seven squamous cell carcinomas of the lip during the years 1948 to 1979. The overall mortality was 19.4% with metastasis developing from lower lip lesions in seven cases.
Explore the source record for details and available documents.
Basal cell carcinoma in black persons is generally believed to be rare, with cases only sporadically reported. Information about 148 basal cell carcinomas found in 128 black patients who were seen at Charity Hospital of Louisiana, New Orleans, between 1948 and 1979, was reviewed. As in whites, most of the tumors occurred on the sun-exposed areas of the head and neck.
Cancer of the skin, in general, is believed to be rather uncommon in black persons. Information from the Tumor Registry of Charity Hospital of Louisiana in New Orleans was reviewed in reference to black patients who were diagnosed as having squamous cell carcinoma (SCC) of the skin between 1948 and 1979. During this period, 163 black patients had a total of 176 SCCs of the skin. The lesions were about 20% more common than basal cell carcinomas (BCCs) in blacks of the same patient population. A mortality of 18.4% was a significant finding. The most common sites of involvement were the face and the lower extremity. Collectively, involvement of the non-sun-exposed areas was more common. The most common predisposing conditions were scarring processes.
Explore the source record for details and available documents.
A 32-year-old black man had a two-year history of malaise, nausea, and vomiting, and a weight loss of 75 lb. Four months before his first clinic visit, a fine papular eruption developed on the torso and ichthyotic lesions found on the arms and legs. Medical evaluation revealed sarcoidosis involving skin, stomach, colon, and liver. To the best of our knowledge, ours is the fifth reported case of ichthyosiform sarcoidosis and the sixth with sarcoidal involvement of the colon.