PubMed HealthSearch

Biomedical subjects

R G Mueller

Publications and source records attributed to R G Mueller.

At least 19 recordsLinked to original sources

ev 22, a new endogenous avian leukosis virus locus found in chickens with spontaneous autoimmune thyroiditis.

Chickens of the Obese strain (OS) develop a hereditary spontaneous autoimmune thyroiditis (SAT) which closely resembles human Hashimoto's disease. Analysis of the endogenous viruses harboured by these animals revealed a new endogenous virus (ev22) detected as a 5.5 kb Sac I fragment. Crossbreeding experiments showed that ev22 is vertically transmitted as an autosomal trait not associated with major histocompatibility (MHC) alleles. Preliminary experiments indicate that ev22 does not necessarily cause SAT, however, it may have a modulatory role in the development of the disease.

Animals

Bubbles in samples for blood gas determinations. A potential source of error.

The presence of small gas bubbles in devices used to collect blood gas samples is considered. A gas bubble whose relative volume is 0.5 to 1% or more that of the liquid in the collection device is a potential source of significant error. Relationships describing the possible magnitude of this error are derived and substantiated.

Blood