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R G Nadeau

Publications and source records attributed to R G Nadeau.

8 recordsLinked to original sources
PubMed2001

The role of a new noninvasive imaging technology in the diagnosis of anemia.

Traditionally, numerical data regarding the status of a patient are a combination of measurements made at the point of care (POC) and those made in the laboratory on specimens withdrawn from the patient. We report here on our experiences with a new method for a noninvasive determination of anemia, as defined by blood hemoglobin (Hb) concentration. This method is based on a novel technology, orthogonal polarization spectral imaging, which provides high quality digitized images of the microcirculation using reflected light. Measurements of Hb, based on the analysis of these images at the POC, were found to compare favorably with results obtained with traditional laboratory methods. Additional advantages of these new POC technologies are that they will make possible completely new measurements that may have no direct analog with existing methods. For example, orthogonal polarization spectral imaging can give feedback regarding microvascular density, which also may be reduced in anemic subjects. This information may give earlier and different insights regarding the patient status in nutritional deficiency anemia than an Hb concentration only. However, additional research will be required to confirm the accuracy and utility of this measurement, especially in adult and pediatric populations, where anemia is more commonly encountered. The ultimate success of POC testing will require collaboration between the attending health care professional, the laboratory and institutional management to rapidly assimilate improved methodologies and new information to provide benefits to the patient.

Anemia↗
PubMed1995

Auditing metabolism studies: a scientist's perspective.

Metabolism studies conducted for submission to regulatory agencies are notorious for presenting difficulties during QA audit. The problems result from many factors, most of which stem from the research nature of such studies. Monsanto-Ceregen's Environmental Science Department (ESD) management has organized a concerted effort to review and change the way our regulatory studies are conducted, especially metabolism studies, with the objective of making the work less expensive in time and money, yet more GLP compliant. The strategy employed toward this objective, which requires that the changes be both developed and implemented by study workers (as opposed to QA workers), is discussed. Examples are given of measures implemented thus far that affect the efficiency and GLP compliance with which our metabolism studies are conducted and audited. These measures fall in two categories: (i) excellent SOPs and (ii) techniques that permit efficient auditing of metabolism study Final Reports.

Documentation↗