Biomedical subjects
Publications and source records attributed to R G Obraztsova.
The article contains data on complex balneotherapy of vibration disease caused by local vibration in high risk group (miners exposed to vibration), that help to justify use of means for primary and secondary prevention of vibration disease.
The authors present results of homeostasis studies in 239 patients having vibration disease due to local vibration and demonstrate drugs-free correction (physio- and balneotherapy) of disorders caused by vibration. High therapeutic efficiency meant improved peripheral hemodynamics of upper limbs, coagulation parameters, lipid metabolism and lipid peroxidation.
Cardiovascular tests in vibraton disease patients revealed failure of efferent vegetative paths. Degree of segmentary neurologic disorders increases as vibration disease progresses.
Clinical and laboratory data are available on affection of the peripheral nervous system (PNS) in 27 patients with Lyme-borreliosis (LB) in the endemic region of Russia. PNS disorders arose early, 88.9% of the patients had them within one month of the disease. 9 (37.5%) patients had meningoradiculoneuropathy (MRN) which emerged in the acute period in 77.8% of the patients. Inflammation in the cerebrospinal fluid was registered only in patients with clinical signs of meningitis. MRN developed more frequently in facial nerve neuritis (FNN) than in radiculopathy (RP)-80.0% and 14.3%, respectively, p = 0.01. Intrathecal synthesis of antibodies to B. burgdorferi in combination with pleocytosis was found only in FNN patients (16.7%). In 6 (37.5%) of 16 patients with neuroborreliosis concentrations of C-reactive protein were elevated. Its high level occurred significantly more frequently in RP (83%) than in FNN (17%) (p = 0.05). 5 out of 14 LB patients exhibited high level of Willebrand factor antigen. No clear clinical relations between this value and PNS lesions in LB were found.
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Clinical characteristics of mixed tick borne encephalitis (TBE) + Lyme borrelliosis (LB) infection and monoinfections are compared. Eighty-five patients with TBE + LB mixed infection serologically verified by EIA and 87 with isolated TBE, who fell ill in 1996, were examined. Among patients with mixed infection, cases with blurred TBE predominated; severe forms (meningeal and focal) were almost two times less incident than in TBE monoinfection. Typical clinical symptoms of LB were observed in 63.5% patients, while in the rest 36.5% LB manifested only by circulation of antibodies to B. burgdorferi. Comparative analysis of patients with mixed TBE + LB infection and TBE monoinfection confirmed a more benign course of TBE during the acute period in patients with mixed infection. Mixed infection should be ruled out or confirmed by thorough clinical examinations with obligatory detection of antibodies to agents of both diseases.
Pathology study of 32 patients who died of tick-borne encephalitis (TBE) in the Ural Region in 1990s revealed differences with this infection registered in 1940-1950s. Pathological changes in the central nervous system by their severity and location are like those observed in the Far East TBE. Apart from grave alterative changes in the nerve cells of motor nuclei of the spinal cord and brain, three types of pathological changes are observed: productive inflammation, exudative inflammation without pronounced inflammatory reaction. Differences in the organism reactions to the infectious process are explained by differences in the virus virulence and organism immunological status.
Specificity marking the evolution and clinical picture of acoustic neurinoma in persons of advanced age is described. A great interest of the cases under study consists in that quite often the clinical picture and the course of the disease in this age category are atypical, this being due to the age of the patients and intercurrent, most often vascular diseases of the brain.
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Explore the source record for details and available documents.