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Biomedical subjects

R G Schamschula

Publications and source records attributed to R G Schamschula.

At least 19 recordsLinked to original sources
PubMed1994

Transient global amnesia following cerebral angiography with non-ionic contrast medium.

Transient global amnesia (TGA) is an uncommon syndrome of recent memory deficit and inability to learn new data, usually resolving within 24 h. Two cases following use of non-ionic contrast media in cerebral angiography are described. The neuroanatomy of memory is reviewed. Possible aetiologies of TGA in relation to cerebral angiography include ischaemia (embolic, arterial spasm), epilepsy that may be primary or tumour-related and direct toxic effects of contrast media.

Adult↗
PubMed1993

Clival chordomas.

Three cases of clival chordomas are reviewed and the findings are compared to those in the recent literature. In the first case the tumour arose from the basion, spreading downwards to invade the upper cervical canal and the paravertebral fascial planes. The second case is a rare case since it affects a 12 year old pre-adolescent boy. The third case showed the characteristic features of petro-clival erosion and a large extracranial component in the nasopharynx. In all three cases, computed tomography was an excellent modality for demonstrating bone destruction, sequestra and calcification but inferior to magnetic resonance imaging (MRI) in demonstrating the soft tissue extent of the tumour. The multiplanar capability of MRI was found to be particularly useful for planning treatment. Vertebral angiography can demonstrate the tumours by vessel displacement, encasement and vascular staining. Two cases had angiography and demonstrated tumour blush. Pre-operative embolization was helpful in one case.

Adult↗
PubMed1988

The fluoride content of selected foods in relation to the fluoride concentration of water.

The F content of foods and beverages comprising a substantial proportion of the Hungarian diet has been determined. Vegetables and fruits grown in three areas where the mean F content of water was 0.09 mg/l, 0.81 mg/l and 1.91 mg/l did not reflect these differences. In contrast, the F content of cooking water has made demonstrable contribution to the F content of cooked foods. Significant elevation in F concentration was also found in some meat products, where the inclusion of bone dust or fragments is suggested by corresponding increase in Ca content.

Beverages↗
PubMed1988

Daily fluoride intake from the diet of Hungarian children in fluoride deficient and naturally fluoridated areas.

Average daily dietary intakes of F were determined for 67 kindergarten children (X age 3.9 years) and 118 schoolchildren (X age 14.0 years), resident in one of three areas where the concentration of naturally occurring F in the household water ranged 0.06-0.11 mg/l, 0.05-1.10 mg/l and 1.6-3.1 mg/l. Mean daily F intakes increased consistently and significantly with increasing F content of the water in all dietary categories in both age groups. Due to relatively low water and high milk consumption, F from foods has made a greater contribution to total F intake (40-53% over the whole sample) than F in water ingested as such, or in beverages. The total amount of F ingested from dietary sources is considered safe even at the highest intake levels found (X = 0.44 mg/day, SD = 0.11 at 3.9 years; 1.49 mg/day, SD = 0.35 at 14.0 years).

Adolescent↗
PubMed1988

Aluminium, calcium and magnesium content of Hungarian foods and dietary intakes by children aged 3.9 and 14 years.

The Al, Ca and Mg content of 147 kinds of foods and beverages, representing a large proportion of the Hungarian diet, has been determined using replicate samples. Dietary intakes of these minerals by 67 kindergarten children and 139 schoolchildren have been assessed. The richest sources of Al were: parsley, celery, gherkins, barley-malt; of Ca: dairy products, celery, parsley, savoy; of Mg: dried beans and peas, parsley, dill, maize-flour, rice, gherkins, chocolate. Flavouring agents (e.g. salt, pepper, paprika, caraway-seed) had very high concentrations of all three minerals and poppy-seeds that of Ca and Mg. The presence of bone-dust or fragments elevated the Ca content of some meats and cooked dishes. The main source of dietary intake of all three minerals was food; as opposed to F, the contribution of water-borne Al, Ca and Mg was negligible. Based on average values, the daily intake of all three minerals was satisfactory in both age groups. Mg intake was marginally below the recommended limit for a few children, but no signs of Mg deficiency were seen.

Adolescent↗
PubMed1988

Fluoride intake and utilization by Hungarian children: associations and interrelationships.

Selected interactions were examined between F, Al, Ca and Mg intakes and their manifestations in dental health parameters and biological samples relating to Hungarian children. The prevalence (DMFT, DMFS) and severity (SR) of caries were inversely related to the F concentration of household water and to the amount of F ingested from foods, beverages and tap or well water. Dental fluorosis and the F content of enamel, plaque, saliva, urine, nails and hair were directly related to the F content of water and to dietary F intake. The high significance levels and absolute consistency of associations lend strong support to the biological interdependence of the variables involved. In contrast, no associations were found between Mg ingestion and F utilization. Despite numerous inverse trends and some statistically significant inverse associations suggesting that dietary Al and Ca interfere with F uptake, the biological significance of the latter findings needs further exploration. Inhaled F amounted to less than 0.17% of the total F intake. The F content of frequently prescribed non-dental medicines ranged from below 0.00001 to 0.014 mg/g; their contribution to total F intake is considered insignificant.

Adolescent↗
PubMed1985

Physiological indicators of fluoride exposure and utilization: an epidemiological study.

Individual samples of urine, fingernails, head-hair, saliva, plaque and enamel were collected from three groups of Hungarian children, aged 14 years, who were exposed to contrasting water fluoride levels (less than or equal to 0.11 ppm; 0.5-1.1 ppm; 1.6-3.1 ppm). The mean fluoride concentration of the samples increased consistently and significantly, but mostly non-proportionately, with increasing water fluoride level. With the exception of plaque, the materials examined are considered suitable indicators of exposure to or systemic utilization of fluoride for population groups. Caries experience decreased with increasing fluoride exposure. Dental fluorosis constituted no clinical or aesthetic problem.

Adolescent↗
PubMed1985

Immediate and delayed effects of an enzyme-dependent mineralizing mouthrinse on dental plaque.

Twenty-two children aged 13 to 14 years rinsed for 3 X 1 min periods with a supersaturated calcium phosphate solution containing urea and monofluorophosphate. Plaque sampled one min after the last rinse showed a marked increase in water-extractable F and a smaller increase in Ca but no increase in water-extractable P. Water-insoluble forms of all three ions were elevated, however. The mean plaque pH was 8.28. Plaque sampled 24 hr after the last rinse showed significant increases in water-insoluble F and Ca only, and no increase in pH. The prompt pH rise and disappearance of water-soluble P suggest that, on exposure to the mineralizing solution, urea and monofluorophosphate are rapidly hydrolyzed by plaque enzymes to provide catabolites which cause the immediate precipitation of fluoridated calcium phosphate.

Adolescent↗
PubMed1983

Increases in fluoride, calcium, and phosphate in dental plaque resulting from the use of a mineralizing mouthrinse containing urea and monofluorophosphate.

A mouthrinse used ten times over a four-day period increased the concentration of acid-extractable fluoride in immature plaque by 320%, calcium by 190%, and phosphate by 97%. Corresponding increases in mature plaque were smaller, yet significant. Diffusion of the ions from plaque was restricted, and hence a prolonged caries-inhibitory effect can be expected.

Calcium↗
PubMed1982

Interrelations between the fluoride concentrations in dental plaque and enamel, and exposure to fluoride.

The F concentrations in plaque and in underlying enamel were determined in a sample of 99 schoolchildren aged 8.4 years (S.D. = 0.37), comprising four groups, exposed life-long to contrasting concentrations of F in the water (range less than or equal to 0.12 ppm to 2.8 ppm) and to supplements of 350 mg F/kg domestic salt. The mean total F concentrations in plaque (dry wt) increased consistently with increasing exposure to F, but the absolute differences were small and the individual variation was high within each group. Significant inverse associations were demonstrated between individual plaque and surface enamel values within two groups, supported by consistent inverse trends (ns) in the remaining groups. These associations and trends are considered to reflect transfer of F from plaque to underlying surface enamel and concommitant reduction in plaque F concentration.

Child↗
PubMed1982

The fluoride content of human tooth enamel in relation to environmental exposure to fluoride.

Double-layer superimposed biopsies were used for sampling sound labial enamel of upper permanent central incisor teeth of 189 children (mean age 8.4 years, SD = 0.36), comprising five groups, representing life-long exposure to contrasting concentrations of F in the water (range less than or equal to 0.12 ppm to 2.8 ppm) and to supplements of 200 or 350 mg F/kg domestic salt. The mean F concentrations of enamel ranged through the groups from 924 ppm to 2401 ppm in the surface layer (average central depth = 0.49 micron) and from 450 ppm to 1428 ppm in the subsurface layer (average central depth = 2.62 microns). The differences between the mean F concentrations of the groups were significant in each instance and the values consistently reflected the extent of F exposure. It was concluded that the F content of enamel is a reliable indicator of environmental exposure to F for populations, but not for every individual.

Child↗
PubMed1981

Oral health of Australian children using surface and artesian water supplies.

Oral health parameters were compared for 6--8 and 10--11-year-old children living in neighbouring. N. S. W. towns, where the community water supplies consisted of artesian and river were respectively. The demographic characteristics, living pattern and dietary carbohydrate challenge were similar in the two areas and effective oral hygiene practices were uniformly lacking. Children in the artesian water area had 40% lower caries prevalence (DIMFT), 50% less severe carious lesions (SR) and significantly better oral hygiene (OHI) and gingival condition (PI) and correspondingly lesser treatment needs than those supplied by river water. The findings were examined in relation to the concentrations of 10 elements in roof catchment, river and artesian water. Apart from a contribution by fluoride to better oral health, the results implicate lithium as a possible beneficial element.

Australia↗