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Biomedical subjects

R G Skvortsova

Publications and source records attributed to R G Skvortsova.

8 recordsLinked to original sources
PubMed2004

[MIRU-VNTR genotyping of Mycobacterium tuberculosis strains from East Siberian: Beijing family versus Kilimanjaro family].

Seventy-two M. tuberculosis strains isolated from patients in different regions of East Siberia were studied by MIRU-VNTR repeats. Phylogenetic trees of relationship between the studied strains and of those from other world regions were investigated by phylogenetic analysis, i.e. NJ, UPGMA and ML. Phylogenetic evidence is provided for the prevalence of Beijing and Beijing-like strains (71%) in the above region. Besides, there was found a group of strains (115%) with the robust genotype which was given the name of ASU (African-Siberian-Ural). A linkage between MIRU10 (5-10 repeat) and MIRU26 (single repeat) was established as a predominant ASU sign. According to preliminary results, apart from Siberia, ASU strains can be encountered in the Urals and Africa (Tanzania, Kilimanjaro genotype). MIRU-VNTR consensus of ASU for East Siberia is 22( > 6)225113233.

DNA, Bacterial↗
PubMed1990

[The electrophoretic mobility of peripheral blood lymphocytes in patients with tuberculosis of the lungs].

The monitoring of the immune system in pulmonary tuberculosis patients and their peripheric blood lymphocyte reaction to its T-system modulators was undertaken by cellular electrophoresis. It was shown that when the lymphocyte subpopulation ratio tends to be normalized in vitro by inoculation with thymalin and T-activin, the given situation can be viewed as an indication to prescribe immunocorrection drugs to these patients. The lymphocyte subpopulation ratio check in the pulmonary tuberculosis subjects by means of the proposed method before and after the thymalin and T-activin treatment made it possible to reveal a significant normalization of the immunologic indices and to achieve better clinical condition of the patients.

Adjuvants, Immunologic↗
PubMed1987

[Morphofunctional evaluation of the immunogenicity of a live brucellosis vaccine].

The possibility of evaluating the immunogenic potency of brucellosis vaccine BA-19 by immunological methods has been shown. Morphometry and the quantitative evaluation of globulin-producing cells in lymphoid organs by direct and indirect immunofluorescent techniques serve as informative evaluation tests. The marker method with the evaluation of lymphocyte classes by acid and alkaline phosphatases and the electrophoretic motility characteristics of T- and B-lymphocytes, used in combination with the above-mentioned methods, present information on immunogenesis. The immunoperoxidase method and the values of the opsonophagocytic index characterize the state of phagocytosis and the persistence of the antigen.

Animals↗