[Zimmermann-positive chromogens in the ether extract of urine in relation to the adrenal cortex function of the rat].
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17-Ketosteroids↗
Biomedical subjects
R Gaggi
Publications and source records attributed to R Gaggi.
[Action of 1:1 combination of phosphorylcholine and homocysteine on liver function, biliary secretion and cholesterolemia in the rat].
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Animals↗
[Comparison of the hematic levels of equiactive doses of oxyphenbutazone in oral and topical administration in experimental phlogosis in the rat].
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Administration, Oral↗
[Action of guanosine and antacids on experimental gastric ulcer induced by reserpine].
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Animals↗
[Protective effect of phosphorylcholine, homocysteine and their combination 1:1 in experimental hepatic lesions rats: comparison with the activity of choline and cysteine].
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Animals↗
[Synthesis and pharmacologic property of anthranilic acid-N-(aryl-substitutes)].
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Animals↗
Effects of isradipine and darodipine on serotonergic system of the rat brain.
Isradipine and darodipine are dihydropyridine calcium antagonists that easily pass into the brain, showing high affinity for cerebral L-type voltage-sensitive calcium channel (VSCC). These drugs were IP administered to rats to study their effects on serotonergic systems of discrete brain areas. Isradipine (0.05-5.0 mg/kg) and darodipine (0.3-20 mg/kg) increased the 5-HIAA/5-HT ratio, mostly enhancing the metabolite (5-HIAA) content in various brain areas, suggesting that serotonin (5-HT) turnover was increased. This increase appeared to depend on facilitation of serotonergic neurotransmission, because low doses of isradipine (< 0.075 mg/kg) or darodipine (< 0.6 mg/kg) enhanced the number of head twitches induced by L-5-hydroxytryptophan (L-5-HTP). However, higher doses of isradipine (1.5 mg/kg) or darodipine (5 mg/kg) also appeared to stimulate a negative feedback mechanism, which predominated over the facilitation when the serotonergic neurotransmission was strongly activated. Thus, higher drug doses decreased both the serotonin turnover and the number of head twitches on rats treated with L-5-HTP. It was speculated that the observed effects were due to brain VSCC blockade, although the studied compounds showed a peculiar profile of properties when compared to other previously studied calcium antagonists. Moreover, it was concluded that darodipine appeared to be more effective and selective than isradipine regarding the effects on brain serotonergic systems.
5-Hydroxytryptophan↗
[Ganglioplegic activities of N1-alkyl derivatives of piridin-beta-carbonic acid diethylamide].
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Animals↗
[Circadian rhythm of rat adrenal gland cholesterol, ascorbic acid and glycogen and corticosterone secretion].
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Adrenal Glands↗
[Circadian variations in rat serum and urinary calcium and phosphorus. Reflections on the Ca/PO4 ratio].
Daily variations of serum and urine calcium and phosphate were determined in young and adult rats of both sexes. The animals were maintained in natural conditions of illumination and feeding ad libitum. The twenty-four hour rhythm of the serum levels and urinary excretion of these electrolytes in male rats is confirmed. This rhythm is markedly modified in young females and less in adult females. Evidence for a circadian rhythm of the Ca/PO4 ratio appears in all groups of rats. The rhythms of serum and urine Ca/PO4 rations are similar in all experimental groups.
Age Factors↗