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Biomedical subjects

R García Caballero

Publications and source records attributed to R García Caballero.

10 recordsLinked to original sources
PubMedDate not supplied

[Correlation between positive skin tests to molds, total IgE, and specific IgE using ELISA and mold cultures from the environment of the pediatric allergy patient].

The aim of this study was to made a correlation between allergic symptoms, positive skin prick test to fungi, total and specific IgE and mold culture in the patient's environmental. There were included 35 children (3-16 years), with skin prick test positive to fungi. The most frequent were: Rhizopus, Aspergillus, Cladosporium and Candida. Total and specific IgE were measured with ELISA, with titers high in 77.2% and 31.4% respectively. Fungal cultures were collected from dwellings and schools. The most frequently isolated mold genera were Cladosporium, Alternaria and Penicillium in the same proportion in both places: dwellings and schools. We concluded fungi are commonly found in children's environment.

Adolescent↗
PubMedDate not supplied

[Air-borne allergens and respiratory allergy in the state of Oaxaca, Mexico].

138 patients from the state of Oaxaca, México, 75 male, 62 female, with an average age of 29 years with diagnosis of asthma rhinitis and sinusitis, were studied to determine the frequency of aeroallergens involved. Scratch tests were carried out with glycerinated antigens, 1:20 w/v Hollister S. The findings show house dust mite to be the allergen most frequently present, followed by house dust, cynodon d and rye grass.

Adolescent↗
PubMedDate not supplied

[Comparison of the cutaneous response to Dermatophagoides farinae from 2 separate laboratories].

We compared in 50 asthmatic children, the cutaneous response by skin prick test to Dermatophagoides farinae with antigens from two different laboratories (Freeman and Hollister). In order to evaluate the importance of the selection, conservation and standardization of the allergic extracts. 27/50 children had a similar response, in those cases (6) where Freeman was doubtful and Hollister positive the allergic etiology was confirmed by RAST and Challenge tests. In 5 cases, Freeman was negative and Hollister doubtful we only confirm allergic etiology in 1. When both were positive all of them were allergic. The antigen Dermatophagoides farinae from Freeman laboratory needs another diagnostic method, when the cutaneous response is doubtful or negative and the clinical feature is highly suggestive. We don't have to forget the importance of the controls positive and negative.

Adolescent↗
PubMedDate not supplied

[Applications and goals of molecular biology].

Clonal studies define the proteic sequence of several allergens leading to the recombination and the use of them for immunotherapy extracts. It has been possible to clone the receptors for IgE in basophils and mast cells and the regulation mechanisms had been delucidates. In a near future it will be possible to design recombinant molecules for the specific inhibition of synthesis and receptors of IgE and avoid the signal transmissions and the release of mediators. The diagnosis of several diseases is based in molecular techniques, inclusive in uterus. Genes for various diseases had been cloned in immunology, recombinations with gamma interferon had been used for treatment of subjects with atopic dermatitis and chronic granulomatous disease.

Allergens↗
PubMedDate not supplied

[Applications and aims of molecular biology].

Clonal studies define the proteic sequence of several allergens leading to the recombination and the use of them for immunotherapy extracts. It has been possible to clone the receptors for IgE in basophils and mast cells and the regulation mechanisms had been delucidated. In a near future it will be possible to design recombinant molecules for the specific inhibition of synthesis and receptors of IgE and avoid the signal transmissions and the release of mediators. The diagnosis of several diseases is based in molecular techniques, inclusive in uterus. Genes for various diseases had been cloned in immunology; recombinations with gamma interferon had been used for treatment of subjects with atopic dermatitis and chronic granulomatous disease.

Humans↗
PubMedDate not supplied

[Early identification of respiratory viruses in asthmatic children].

The role of viral infections as a part of the environmental factors that triggered asthma in atopic subjects, their age specific pattern, as well as many risk factors for the development of subsequent wheezing are described. Some pathogenic mechanisms and their importance in the induction of airway inflammation are mentioned and early identification by laboratory tests in outlined for preventive approach and early antiinflammatory treatment.

Asthma↗
PubMedDate not supplied

[Viruses precipitating asthmatic crises].

Study made with 45 patients in the allergy service of the Instituto Nacional de Pediatría, with the purpose of analyzing the virus participation in the precipitation of asthmatic crisis in children who lived in the southeast of Mexico City. The subjects were included in the study if they presented signs of atopy or infection of the superior air channels. Pollen allergics, rhinosinusitis, smokers relatives and patients who own pets were excluded. In this population group, the participation of the virus were RSV, influenza B and parainfluenza.

Adolescent↗
PubMedDate not supplied

[Arterial oxygen saturation versus peak expiratory flow as predictive values in the course of asthmatic crises in children].

Asthmatic crisis is one of the most frequent urgencies in children. One of the most difficult decision for a physician is to determine what patient requires only ambulatory treatment and what patient needs hospital treatment. Many investigators have developed predictive scores, but to date conclusions are confusing. The purpose of the present study was to compare the value of arterial oxygen saturation versus peak expiratory flow rate measurements as predictors of the outcome of the asthmatic crisis in children. We performed a prospective, longitudinal, observational, comparative study in 50 children (30 males, 20 female), with ages between 6 and 18 years old, with the presence of a moderate asthmatic crisis. We measured arterial oxygen saturation and peak expiratory flow rate at the moment of their arrival to urgencies and at 30 minutes, 2, 4 and 24 hours after the administration of nebulized albuterol (100 mcg/k/dose). We found significant differences on baseline arterial oxygen saturation and the registrations taken at 2, 4, and 24 hours posttreatment (0.01), and we could only find significant differences between baseline peak expiratory flow rate and the registrations taken at 24 hours pretreatment. In conclusion arterial oxygen saturation is a better predictor than peak expiratory flow rate in the evolution of the asthmatic crisis in children.

Adolescent↗
PubMedDate not supplied

[Levocabastine versus cetirizine for perennial allergic rhinitis in children].

OBJECTIVE: To compare the efficacy and safety of levocabastine nasal spray asid cetirizine oral for the treatment of perennial allergic rhinitis in children. MATERIAL AND METHODS: In this randomized, prospective experimental, open clinical trial. We studied 30 children with ages between 6 and 16 years with perennial allergic rhinitis. Group 1, 17 subjects (7 female, 10 male) received cetirizine once daily, 5 mg children weientig less dian 30 k asid 10 mg in children weighing more trw' 30 k during 15 days. Group 2, 13 subjects (7 male, 6 female) received levocabastine 2 puffs BID on each nostril during tbe same time. A nasal symptoms score, nasal peal: flow vid eosinophils in a nasal smear were performed before and after treatment. RESULTS: There were no statistical differences in age, weight, height and arid duration of symptoms. Both groups showed improvement of symptoms via nasal peak flow with no differences between them (intergroup); nasal eosinophils remained unchanged. We for third statistical differences pre vid postreatment in each group (intragroup): Group 1, nasal congestion p = 0.002, ocular itch p = 0.01, sneezing p = 0.007, nasal secretion p = 0.01, nasal itch O = 0.009, total points O = 0.0005. Group 2, nasal congestion O = 0.02, ocular itch p = 0.05, sneezing p = 0.01, nasal secretion p = 0.01, nasal itch p = 0.04, total points p = 0.005. Significant differences were found in nasal peal' flow in Group 1 (p = 0.01) but no differences in eosinophils between file two groups. Side effects: 3 subjects in Group 1 (drowsiness, 1 appetite increase said 1 rhinorrea with epistaxis) vide 1 in Group 2 sensation of facial edema. CONCLUSION: Bofil drugs are effective the clinical relief of symptoms of perennial allergic rhinitis in children vied levocabastine has less side effects.

Adolescent↗