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Biomedical subjects

R García-González

Publications and source records attributed to R García-González.

13 recordsLinked to original sources
PubMed2000

Testicular metastases from solid tumors: an autopsy study.

In a retrospective study of 738 consecutive autopsies of adult males with solid malignant neoplasms, five (0.68%) were shown to have metastatic deposits within the testis. These were metastases from bronchial carcinoma (three cases), melanoma (one case), and pancreatic endocrine carcinoma (one case). The mean age of the patients with solid tumors metastatic to the testis was 60 years (range, 32 to 83 years). The metastases from the solid tumors presented two patterns: destructive and/or focal interstitial. The destructive pattern was characterized by sheets of malignant cells that destroyed and replaced the seminiferous tubules. The interstitial pattern was characterized by tumor cells within the interstitium without involvement of the seminiferous tubules. All metastases showing the destructive pattern were macroscopically evident. Approximately 40% of the metastatic deposits were microscopic and showed a focal interstitial pattern. These cases are not easily identified unless a sufficient number of tissue blocks are sampled and carefully scrutinized. In 20% of the cases the metastatic deposits were bilateral. Improved diagnostic skills and treatment protocols in the last 11 years apparently have not significantly affected incidence, distribution, or the pattern of metastatic spread of solid tumors to the testis.

Adult↗
PubMed1999

Indinavir crystallization and urolithiasis.

The crystallization of indinavir in synthetic urine at different pH values and indinavir concentrations was kinetically studied. It was found that precipitation time notably decreases at urinary pH values above 6.0. The effects of some products as potential crystallization inhibitors were studied. Some natural saponins such as escin and glycyrrhizic acid provoked a notable increase in the precipitation time of indinavir, this pointing out their possible use to prevent renal tubular solid deposition.

Chemical Precipitation↗
PubMed1998

Amyloidosis of the rectum mimicking collagenous colitis.

Gastrointestinal involvement in cases of systemic amyloidosis is very common. In the colorectal mucosa, amyloid deposition is ordinarily seen around vessels or diffusely in the lamina propria. We report two cases in men aged 69 and 29 years, whose rectal biopsies revealed prominent subepithelial amyloid deposits mimicking collagenous colitis. The amyloid deposits were composed of AA protein. A review of the literature has yielded only one previously reported case. Pathologists should be aware of this deposition pattern of amyloid to prevent misdiagnosis. Our cases underline the importance of the routine use of histochemical stains for amyloid in all cases of colorectal biopsies showing histologic changes suggestive of collagenous colitis.

Adult↗
PubMed1992

[Value of fine needle aspiration cytology in the diagnosis and treatment of tumors].

UNLABELLED: We report the cytologic results of 186 fine needle aspirations on accessible lymph nodes and tumoral masses as well as deep masses under radiologic control. We assessed the ratios of diagnostic accuracy and the utility of this procedure for staging solid tumors and taking therapeutic decisions. RESULTS: sensitivity, 89.6%; specificity, 100%; positive predictive value, 100%; negative predictive value, 57% and accuracy index, 89.2%. Using this technique we detected a metastatic disease in 62% of neoplastic patients. We took a therapeutic decision (active treatment or analgesia) in accordance with the results of the cytology in 63% of patients with solid tumors. Two patients, after a transthoracic aspiration, developed pneumothorax as a complication. Cytology by fine needle aspiration is a fast and simple method for diagnosing, staging and taking a therapeutic decision on patients with solid tumors.

Adult↗
PubMed1986

The functional value of collateral testicular vascularisation. An experimental study.

The functional value of the collateral testicular vascularisation has been studied in the rat. In some cases the spermatic artery was sectioned at different levels and in others the vasal artery was sectioned. Hormonal, pathological and anatomical parameters were investigated. The results support the concept that the vasal artery is the most important collateral artery and that the cremasteric artery plays little, if any, part. They also support the view that following proximal section of the testicular artery, the collateral testicular blood supply is variable and the effects of this division are unpredictable and inconsistent.

Animals↗