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Biomedical subjects

R Garzón

Publications and source records attributed to R Garzón.

12 recordsLinked to original sources
PubMed2001

Myelodysplastic syndromes: a community hospital-based study of prognostic factors and International Prognostic Scoring System.

Various prognostic factors and the International Prognosis Scoring System (IPSS) were assessed in our community hospital-based retrospective study of 55 cases of myelodysplastic syndromes (MDS). All cases were reviewed for clinical, hematologic, histopathologic, and cytogenetic data. The median follow-up was 1.61 years. Twenty patients (36%) were classified as refractory anemia (RA); seven (13%) as refractory anemia with ringed sideroblasts (RARS); 13 (24%) as chronic myelomonocytic leukemia (CMML); 11 (20%) as refractory anemia with excess blasts (RAEB); and four (7%) as refractory anemia with excess blasts in transformation (RAEB-t). Twenty-seven (49%) died during the follow-up period, seven with acute myelogenous leukemia (AML). The median survival was 2.8 years. The variables that showed association with survival by univariate analysis included the absolute neutrophil count, French-American-British (FAB) subtype, percentage of blasts, number of cytopenias, abnormal localization of immature precursors, and IPSS score. When entered into a regression model, IPSS showed a trend towards an association with survival (P 0.09). We conclude that the IPSS can prognostically stratify MDS patients. However, no independent prognostic factor was confirmed in our analysis. Further studies are needed to assess the utility of IPSS.

Aged↗
PubMed2001

[Marjolin ulcer].

Marjolin's ulcers can produce neoplasms. They appear on previous scars produced by old three degree burns. Sometimes they appear after 50 years of the previous accident. Three patients showing squamous cell epitheliomas are presented, and the opportunity and technique of the surgical treatment is discussed.

Burns↗
PubMed2000

[Prototype of light source for photodynamic therapy in Centre of Electron Microscopy].

The Photodynamic Therapy (PDT) is a cancer treatment based on specific accumulation of a photosensitizer in the malignant tissue and its subsequent irradiation at appropriate wave lengths induce the production of oxygen singlets responsible for peroxidation of cell organelles and cell death. A prototype of a 630 nm non coherent light source designed and constructed at the Centre of Electron Microscopy of The Cordoba National University allowed a successful application of PDT, in nonmelanoma skin tumors, for the first time in this Country. A topical treatment with 20% delta aminolevulinic acid (ALA) in aqueous solution was applied in 100 lesions of actinic keratosis of 27 patients. The results obtained in this study were the following: Complete Remission (RC) 84%, Partial Remission (RP) 10%, No Response (SR) 0% and No data (SD) 6%. In the latter group are included those patients who did not return for reevaluation. The high efficiency plus the excellent cosmetic response and low aggressiveness, make the PDT the method of choice treatment of this skin pathology. In addition to be no invasive and well tolerated, the prototype of light source used in this study, was remarkably effective.

Aged↗
PubMed2000

[Acute eosinophilic pneumonia. Case report and review of the literature].

A 37 year old female smoker was admitted with an acute episode of fever and pulmonary infiltrates followed by respiratory failure requiring mechanical ventilation in less than 24 hours. After empiric antibiotic therapy fiberoptic bronchoscopy and bronchoalveolar lavage (BAL) were carried out. Abnormal findings were limited to highly increased eosinophilic count in BAL. Blood eosinophils were normal. Acute eosinophilic pneumonia was diagnosed and methyl prednisolone was administered; 48 hours afterwards, infiltrates had partially resolved and the patient was weaned from ventilator. After two years follow up, she has not had recurrences of the episode, is asymptomatic and her chest Xray is normal. A review of the literature is presented and physiopathological mechanisms for acute eosinophilic pneumonia are considered. Acute eosinophilic pneumonia is a rare but potentially curable cause of respiratory failure that should be included in diagnostic considerations.

Acute Disease↗
PubMed1992

[Postoperative gallbladder and systemic candidiasis].

Gangrenous cholecystitis occurred in an immunodepressed patient with generalized neoplasia. Evolution was rapid and severe. Emergency cholecystectomy and systemic treatment with Anphotherycin were life-saving.

Adult↗
PubMed1984

Genetic markers in the blood of Spanish goat breeds.

Biochemical variation of four genetic markers (Hb, Al, Tf, 'X' protein) in the blood of four Spanish goat breeds was analysed with starch gel electrophoresis. The frequencies at all of these loci have been calculated for the Spanish goats and compared with some of the goat breeds studied so far by other authors.

Animals↗
PubMedDate not supplied

[Consumption of medications in people over age of 65 years: potential problems and associated factors].

OBJECTIVE: To determine the percentage of patients over 65 years of age with potential problems derived from the consumption of medications, and identify associated variables. DESIGN: A descriptive cross-sectional study. SETTING: Otero y Paulino Prieto Health Centers (Oviedo). PATIENTS: A randomly selected group of 298 patients over 65 years. MEASUREMENTS AND RESULTS: A questionnaire using both interview and clinical case notes provided data about sociodemographic details, perceived state of health, and functional status of patients, and qualitative and quantitative aspects of pharmacological treatment. 222 valid questionnaires were obtained. Once having identified patients with potential treatment problems, the associated variables were studied using bivariant and multivariant analysis. The mean consumption of medications was 3.1. 32.9% of patients had treatment problems (95% CI, 26.7-39.1), identified as drug interactions (54.8%), inappropriate use (36.9%) or both (8.3%). The bivariant analysis showed an association between the presence of problems and number of medications consumed (p < 0.001), prescribers (p < 0.001), diagnostic (p < 0.001), number of visit/year (p < 0.004), patient's own perception of health (p = 0.006), age (p = 0.018), socioeconomic status (p = 0.024) and cultural level (p = 0.039); the associations was not significative for functional status (p = 0.150), sex (p = 0.246), and number of UTB (Use Therapeutic Low) drug used (p = 0.751). Logistic regression showed an association between the presence of problems and patient's perceived state of health (OR, 1.56; 95% CI, 1.03-2.36) and the number of medications consumed (OR, 1.67; 95% CI, 1.41-2). CONCLUSIONS: A third of the population studied showed potential problems derived from the consumption of medications, through drug interactions and/or inappropriate use. Variables associated with this problems are the patient's perceived ill-health, and the highest consumption of medications.

Aged↗