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Biomedical subjects

R Genova

Publications and source records attributed to R Genova.

At least 19 recordsLinked to original sources
PubMed1986

Thymomodulin in management of food allergy in children.

We studied 44 children, 7 months to 14 years old (15 males and 29 females), diagnosed for food allergy from the symptomatology, anamnestic data information, physical examination, determination of IgG/IgA/IgE plasmatic levels, and the application of the Prick test and RAST. The anamnestic data revealed a high prevalence of cow's milk feeding during the first 6 months of life, and a high incidence of allergies in the family, the mother being the most frequently affected relative. The children had a low IgA plasmatic level (56.78 +/- 6.3 mg%) and a high IgE plasmatic level (389 +/- 35 U/ml). RAST proved to be positive only in 28% of the subjects; the Prick test showed a better correlation with the symptomatology. The children were divided into groups A and B and submitted to an exclusion diet for 6 months, group B receiving oral Thymomodulin. At the end of this treatment period, a better food tolerance was achieved in the group of children treated with Thymomodulin combined with the exclusion diet. The oral challenge which induced a relapse of clinical symptomatology in 68% of the subjects in group A, induced it in only 29% of the subjects in group B. Furthermore, clinical manifestations were less severe in group B. In the group B children, the IgE plasmatic level showed a significant decrease (228 +/- 6 U/ml) (p less than 0.005), and the IgA plasmatic level rose to 98.35 +/- 8 mg% (p less than 0.01). No modifications were observed in the other immunological parameters studied. It is concluded that oral Thymomodulin combined with an exclusion diet was very effective in preventing food allergy relapses.

Adolescent↗
PubMed1985

The quantitative determination of neomycin sulphate by a diffusion technique on agar plates by the method of the European Pharmacopoeia, 2nd edition--evaluation of precision and reproducibility of the method.

The medium recommended by the European Pharmacopoeia (EP), 2nd edition, for the microbiological determination of neomycin by the agar diffusion method was tested and compared with the medium recommended by the EP, 1st edition. The tests were carried out in different laboratories. The medium recommended by the EP, 2nd edition, gave greater precision and reproducibility than the previous medium. The possibility of using a reference standard of almost pure neomycin B for both the determination of framycetin and neomycin was evaluated. The results demonstrated that the medium recommended by the EP, 2nd edition, gave better precision and reproducibility. Difficulty in achieving valid assays was practically the same with both media.

Bacillus subtilis↗