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Biomedical subjects

R Gerritse

Publications and source records attributed to R Gerritse.

14 recordsLinked to original sources
PubMed1988

Influence of salazosulphapyridine and 5-aminosalicylic acid on seminal qualities and male sex hormones.

Seminal abnormalities are a common side effect of salazosulphapyridine (SASP) treatment. We evaluated semen qualities and sex hormone concentrations in 11 patients with inflammatory bowel disease (IBD) during SASP treatment and 4 months after replacing SASP with an oral slow-release preparation of 5-aminosalicylic acid (5-ASA). Significant improvement in sperm count (p less than 0.01), morphology (p less than 0.02), and motility (p less than 0.02) could be observed during 5-ASA therapy, in comparison with SASP treatment. Three pregnancies occurred during the study period. The serum concentrations of gonadotrophins, prolactin, and sex hormone-binding globulin were normal in all patients and not significantly different in the two treatment periods. The mean total testosterone concentration decreased significantly (p less than 0.02) after 5-ASA substitution, together with serum albumin (p less than 0.005), although all values remained within normal limits. The apparent free testosterone concentration was not significantly different in the two treatment periods. It is concluded that a significant improvement in semen quality can be obtained in male patients with IBD after replacing SASP with 5-ASA.

Adult↗
PubMed1985

Antidiuretic effect of ritodrine with and without beta-adrenergic blockade.

Dose-related effects of ritodrine and ritodrine combined with metoprolol on urinary excretion rate were studied in anesthetized dogs. Urine production was abruptly reduced after a total dose of 4 micrograms.kg-1 of ritodrine. This effect could not be antagonized by metoprolol, although the ritodrine-induced decrease of mean arterial pressure and renal arterial blood flow was significantly inhibited. The possible role of fluid retention during tocolytic treatment, even with beta-adrenergic blockade, in the etiology of pulmonary edema is discussed with a review on recent literature.

Adrenergic beta-Antagonists↗
PubMed1985

Cardiovascular effects of ritodrine are blocked by metoprolol in the anesthetized dog.

Inhibition of ritodrine-induced cardiac and peripheral vascular effects by the beta 1-adrenergic blocker metoprolol, was studied by electromagnetic flow measurements in anesthetized dogs. As expected, metoprolol inhibited the ritodrine-induced/increased cardiac workload and heart rate. Metoprolol also inhibited ritodrine-induced peripheral vasodilation. This leads to questions about the cardiac beta 1-adrenergic selectivity of metoprolol. Regarding earlier studies showing no interference in labor inhibition, the combination of ritodrine and metoprolol might be useful in treatment of preterm labor, while economizing cardiovascular performance centrally as well as peripherally.

Anesthesia↗
PubMedDate not supplied

Dose-related effects of fenoterol and ritodrine in 10 peripheral vascular beds of the anesthetized dog.

Dose-response curves of the uterine relaxants fenoterol and ritodrine were established for vascular conductance in 10 peripheral arterial beds in anesthetized dogs. Vascular sensitivity was expressed as (E)D50 of conductance response. Fenoterol induced strong vasodilation in all arterial beds except in the kidneys. The gastrointestinal vessels are significantly more sensitive to fenoterol than are muscle and brain vessels. Ritodrine induced strong vasodilation in all arterial beds except in the kidneys and the liver. The vascular sensitivity spectrum of ritodrine differs from that of fenoterol. On a molecular basis fenoterol was 66 times as potent as ritodrine if arterial pressure reduction was used as criterion. When (E)D50 values of vascular conductances of both drugs were plotted against arterial pressure reduction as reference, the gastrointestinal vessels (left gastric, splenic, gastroduodenal, proper hepatic, and superior mesenteric arteries) appeared to be significantly more sensitive to fenoterol than to ritodrine. In contrast, vascular sensitivity in the myocardium, striated muscles, and brain (left coronary, common carotid, femoral, and vertebral arteries) was not statistically different for the two drugs.

Anesthesia↗
PubMedDate not supplied

Maturation of bovine oocytes transplanted into bovine follicles of follicular and luteal phase.

Forty-one bovine host follicles with guest oocytes were studied. Fifty of these host follicles from the follicular phase and 26 follicles from the luteal phase of the cycle were cultured in a continuous flux system. No hormones were added to the follicular fluid or the culture medium. After culturing there was no close contact between the oocyte complex and the follicular wall. Of the oocytes cultured in the follicular-phase follicles, 27.2% remained in the germinal vesicle stage and 7.1% reached MII, whereas 9.9% of the oocytes cultured in the luteal-phase follicles remained in germinal vesicle phase and 29.5% reached MII. Of the oocytes cultured in the luteal-phase host follicles, 15.2% were fertilized in vitro; none of the oocytes cultured in follicular-phase follicles were fertilized.

Animals↗